Lovastatin decreases the synthesis of inflammatory mediators in the hippocampus and blocks the hyperthermia of rats submitted to long-lasting status epilepticus

Lovastatin decreases the synthesis of inflammatory mediators in the hippocampus and blocks the hyperthermia of rats submitted to long-lasting status epilepticus

Author Furtado Gouveia, Telma Luciana Autor UNIFESP Google Scholar
Scorza, Fulvio Alexandre Autor UNIFESP Google Scholar
Vieira Silva, Michele Juliana Autor UNIFESP Google Scholar
Bandeira, Tatiane de Aquino Autor UNIFESP Google Scholar
Perosa, Sandra Regina Autor UNIFESP Google Scholar
Arganaraz, Gustavo Adolfo Autor UNIFESP Google Scholar
Silva, Marcelo de Paula Autor UNIFESP Google Scholar
Araujo, Thiago Rodrigues Autor UNIFESP Google Scholar
Berzaghi Frangiotti, Maria Isabel Autor UNIFESP Google Scholar
Amado, Debora Autor UNIFESP Google Scholar
Cavalheiro, Esper Abrao Autor UNIFESP Google Scholar
Silva, Jose Antonio Google Scholar
Naffah-Mazzacoratti, Maria da Graca Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Univ Nove Julho
Univ Fed Rio Grande do Norte
Abstract Statins may act on inflammatory responses, decreasing oxidative stress and also reducing temperature after a brain ischemic insult. Previous data have indicated that statins protect neurons from death during long-lasting status epilepticus (SE) and attenuate seizure behaviors in animals treated with kainic acid. in this context, the study described here aimed to investigate the effect of lovastatin on body temperature and on mRNA expression levels of hippocampal cytokines such as interleukin-1 beta, interleukin-6, tumor necrosis factor a, and kinin B1 and B2 receptors of rats submitted to pilocarpine-induced SE. Quantitative real-time polymerase chain reaction showed a significant decrease in mRNA expression of interleukin-1 beta, interleukin-6, tumor necrosis factor a, and kinin B1 receptor in animals with SE treated with lovastatin, compared with untreated animals with SE (P<0.001). Lovastatin also reduced SE-induced hyperthermia, indicating that mechanisms related to brain protection are triggered by this drug under conditions associated with acute excitotoxicity or long-lasting SE. (c) 2010 Elsevier Inc. All rights reserved.
Keywords Lovastatin
Inflammatory mediators
Hippocampus
Temporal lobe epilepsy
Neuroprotection
Language English
Sponsor Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
CinAPCe
Date 2011-01-01
Published in Epilepsy & Behavior. San Diego: Academic Press Inc Elsevier Science, v. 20, n. 1, p. 1-5, 2011.
ISSN 1525-5050 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 1-5
Origin http://dx.doi.org/10.1016/j.yebeh.2010.10.001
Access rights Closed access
Type Article
Web of Science ID WOS:000287331300001
URI http://repositorio.unifesp.br/handle/11600/33295

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