Labeling index in pituitary adenomas evaluated by means of MIB-1: is there a prognostic role? A critical review

Labeling index in pituitary adenomas evaluated by means of MIB-1: is there a prognostic role? A critical review

Author Pires de Aguiar, Paulo Henrique Google Scholar
Aires, Rogerio Google Scholar
Laws, Edward R. Google Scholar
Isolan, Gustavo Rassier Google Scholar
Logullo, Angela Autor UNIFESP Google Scholar
Patil, Chirag Google Scholar
Katznelson, Laurence Google Scholar
Institution Universidade de São Paulo (USP)
Santa Casa de Londrina Hosp
Brigham & Womens Hosp
Univ Fed Rio Grande do Sul
Universidade Federal de São Paulo (UNIFESP)
Stanford Univ
Abstract Objective: the present article presents an overview of the literature, and analyses the methods and the primary questions related to assessment of proliferation index using the Ki-67/MIB-1 labeling index in pituitary adenomas. Although atypical adenomas are characterized by their atypical morphological features by an elevated mitotic index, a Ki-67 (MIB-1) labeling index greater than 3% and extensive nuclear staining for p53, use of the proliferation index (LI) of pituitary adenomas in assessing the degree of tumor aggressiveness is a controversial topic in the literature, and there are disparate results involving many studies.Methods: A review of literature was carried out to correlate the role of Ki-67 LI and its correlation with clinical findings, tumor size, invasiveness, recurrence, adenoma subtype, adenoma doubling time, and pituitary carcinomas is addressed. Results: the prognosis cannot be predicted on the basis of the Ki-67 LI alone. Although there is no direct relation between Ki-67 LI and some of these variables and controversial data were found regarding some topics, our review justify the use of Ki-67 in the analysis of pituitary adenomas as an additional information for clinical decision.Conclusion: Although assessment of proliferative may be helpful in predicting subsequent tumor recurrence or invasiveness, there are many other important and as yet unidentified factors pituitary tumors. It is clear that further research is needed to clarify these molecular mechanisms to predict those with a potentially poor clinical outcome.
Keywords Pituitary adenomas
Labeling index
Cell growth
Invasion
MIB-1
Ki-67
Language English
Date 2010-12-01
Published in Neurological Research. Leeds: Maney Publishing, v. 32, n. 10, p. 1060-1071, 2010.
ISSN 0161-6412 (Sherpa/Romeo, impact factor)
Publisher Maney Publishing
Extent 1060-1071
Origin http://dx.doi.org/10.1179/016164110X12670144737855
Access rights Closed access
Type Review
Web of Science ID WOS:000283422300008
URI http://repositorio.unifesp.br/handle/11600/33159

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