Low CD4(+) T-Cell Levels and B-Cell Apoptosis in Vertically HIV-exposed Noninfected Children and Adolescents

Low CD4(+) T-Cell Levels and B-Cell Apoptosis in Vertically HIV-exposed Noninfected Children and Adolescents

Author Miyamoto, Maristela Google Scholar
Pessoa, Silvana D. Google Scholar
Ono, Erika Google Scholar
Machado, Daisy M. Google Scholar
Salomão, Reinaldo Autor UNIFESP Google Scholar
Succi, Regina C. de M. Google Scholar
Pahwa, Savita Google Scholar
Moraes-Pinto, Maria Isabel de Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Univ Miami
Abstract Lymphocyte subsets, activation markers and apoptosis were assessed in 20 HIV-exposed noninfected (ENI) children born to HIV-infected women who were or not exposed to antiretroviral (ARV) drugs during pregnancy and early infancy. ENI children and adolescents were aged 6-18 years and they were compared to 25 age-matched healthy non-HIV-exposed children and adolescents (Control). ENI individuals presented lower CD4(+) T cells/mm(3) than Control group (control: 1120.3 vs. ENI: 876.3; t-test, p=0.030). ENI individuals had higher B-cell apoptosis than Control group (Control: 36.6%, ARV exposed: 82.3%, ARV nonexposed: 68.5%; Kruskal-Wallis, p < 0.05), but no statistical difference was noticed between those exposed and not exposed to ARV. Immune activation in CD4(+) T, CD8(+) T and in B cells was comparable in ENI and in Control children and adolescents. Subtle long-term immune alterations might persist among ENI individuals, but the clinical consequences if any are unknown, and these children require continued monitoring.
Keywords Human Immunodeficiency Virus
apoptosis
lymphocyte activation
antiretroviral agents
CD4 T cell
B cell
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Miami Fogarty
Miami Developmental Center for AIDS Research
Grant number FAPESP: 04/15316-4
FAPESP: 04/15317-0
Miami Fogarty: AITRP5D43TW000017
Miami Developmental Center for AIDS Research: P30AI073961
Date 2010-12-01
Published in Journal of Tropical Pediatrics. Oxford: Oxford Univ Press, v. 56, n. 6, p. 427-432, 2010.
ISSN 0142-6338 (Sherpa/Romeo, impact factor)
Publisher Oxford Univ Press
Extent 427-432
Origin http://dx.doi.org/10.1093/tropej/fmq024
Access rights Closed access
Type Article
Web of Science ID WOS:000284645100010
URI http://repositorio.unifesp.br/handle/11600/33149

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