MECHANICAL STIMULATION IMPROVES SURVIVAL in RANDOM-PATTERN SKIN FLAPS in RATS

MECHANICAL STIMULATION IMPROVES SURVIVAL in RANDOM-PATTERN SKIN FLAPS in RATS

Author Tacani, Pascale Mutti Autor UNIFESP Google Scholar
Liebano, Richard Eloin Autor UNIFESP Google Scholar
Pinfildi, Carlos Eduardo Autor UNIFESP Google Scholar
Gomes, Heitor Carvalho Autor UNIFESP Google Scholar
Arias, Victor Eduardo Autor UNIFESP Google Scholar
Ferreira, Lydia Masako Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Univ City São Paulo UNICID
Abstract This was a study on the effects of 3-MHz ultrasound at 16- and 100-Hz pulse repetition frequencies on angiogenesis and viability of random-pattern skin flaps in rats. A cranially-based dorsal skin flap was raised in 60 EPM-Wistar rats, which were randomly divided into four groups: control, sham, 16-Hz and 100-Hz groups. the mean percentage of necrosis was as follows: control, 42% +/- 13%; sham, 18% +/- 13%; 16-Hz group, 13% +/- 10%; and 100-Hz group, 15% +/- 7%, with significant differences between the control and the other groups (p < 0.001). the mean vascular density was as follows: control, 5% +/- 2%; sham, 7% +/- 2%; 16-Hz group, 21% +/- 4%; and 100-Hz group, 24% +/- 10%, with significant differences between control and ultrasound groups, and between the sham and ultrasound groups (p < 0.001). Both ultrasound treatments (16- and 100-Hz PRFs) induced angiogenesis, and sham and ultrasound treatments improved viability of random-pattern skin flaps in rats. (E-mails: pascale.tacani@hotmail.com; sandra.dcir@epm.br) (C) 2010 World Federation for Ultrasound in Medicine & Biology.
Keywords Microcirculation
Necrosis
Physiologic neovascularization
Rats
Surgical flaps
Ultrasonic therapy
Ischemia
Skin
Plastic surgery
Physical therapy modalities
Language English
Date 2010-12-01
Published in Ultrasound in Medicine and Biology. New York: Elsevier B.V., v. 36, n. 12, p. 2048-2056, 2010.
ISSN 0301-5629 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 2048-2056
Origin http://dx.doi.org/10.1016/j.ultrasmedbio.2010.07.020
Access rights Closed access
Type Article
Web of Science ID WOS:000284334400011
URI http://repositorio.unifesp.br/handle/11600/33139

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