Effects of growth hormone on body proportions in Turner syndrome compared with non-treated patients and normal women

Effects of growth hormone on body proportions in Turner syndrome compared with non-treated patients and normal women

Author Baldin, A. D. Google Scholar
Fabbri, Tatiana Autor UNIFESP Google Scholar
Siviero-Miachon, A. A. Autor UNIFESP Google Scholar
Spinola-Castro, A. M. Autor UNIFESP Google Scholar
Lemos-Marini, S. H. V. Google Scholar
Baptista, M. T. M. Google Scholar
D'Souza-Li, L. F. R. Google Scholar
Maciel-Guerra, A. T. Google Scholar
Guerra-Junior, G. Google Scholar
Institution Universidade Estadual de Campinas (UNICAMP)
Universidade Federal de São Paulo (UNIFESP)
Abstract Background: the majority of anthropometric assessments in Turner syndrome (TS) patients has focused on height. AIM: To analyze body proportions in young adult TS patients either treated or not treated with rhGH, and to compare them with a group of age-matched healthy women. Subjects and methods: Standing height, sitting height, weight, foot and leg lengths, arm span, head circumference, biliac and bi-acromial diameters were measured in 52 non-treated TS patients, 30 treated with rhGH and 133 healthy women. Results: Age at the start of rhGH therapy varied from 7.8 to 15.1 yr (10.0 +/- 1.3 yr), the duration of treatment from 2.8 to 8.2 yr (3.7 +/- 1.5 yr) and the mean recombinant human GH (rhGH) dose was 0.42 mg/kg/week (from 0.32 to 0.50 mg/kg/week). Non-treated patients did not show any difference in anthropometric variables when compared with the treated ones, except for hand length (p=0.02) and height (p=0.05), which were increased in the treated group. All anthropometric variables, except head circumference, were different when comparing TS patients (either treated or not) with age-matched healthy women. Conclusion: Brazilian TS patients either treated or not with rhGH showed almost no differences in terms of their body proportions. This result is probably due to the late age at the start of treatment, and/or the short period of rhGH administration. Hand length was different between the groups, showing the importance of including the extremities in body proportion assessment during rhGH treatment of TS patients. (J. Endocrinol. Invest. 33: 691-695, 2010) (C) 2010, Editrice Kurtis
Keywords Turner syndrome
growth hormone
body proportions
height
weight
Language English
Sponsor Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Date 2010-11-01
Published in Journal of Endocrinological Investigation. Milan: Editrice Kurtis S R L, v. 33, n. 10, p. 691-695, 2010.
ISSN 0391-4097 (Sherpa/Romeo, impact factor)
Publisher Editrice Kurtis S R L
Extent 691-695
Origin http://link.springer.com/article/10.1007/BF03346671
Access rights Closed access
Type Article
Web of Science ID WOS:000286797500002
URI http://repositorio.unifesp.br/handle/11600/33074

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