Absence of gender effect on amygdala volume in temporal lobe epilepsy

Absence of gender effect on amygdala volume in temporal lobe epilepsy

Author Silva, Ivaldo Autor UNIFESP Google Scholar
Lin, Katia Google Scholar
Jackowski, Andrea P. Autor UNIFESP Google Scholar
Centeno, Ricardo da Silva Autor UNIFESP Google Scholar
Pinto, Magali L. Autor UNIFESP Google Scholar
Carrete, Henrique Autor UNIFESP Google Scholar
Yacubian, Elza Márcia Targas Autor UNIFESP Google Scholar
Amado, Debora Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Sexual dimorphism has already been described in temporal lobe epilepsy with mesial temporal sclerosis (TLE-MTS). This study evaluated the effect of gender on amygdala volume in patients with TLE-MTS. One hundred twenty-four patients with refractory unilateral or bilateral TLE-MTS who were being considered for epilepsy surgery underwent a comprehensive presurgical evaluation and MRI. Amygdalas of 67 women (27 with right; 32 with left, and 8 with bilateral TLE) and 57 men (22 with right, 30 with left, and 5 with bilateral TLE) were manually segmented. Significant ipsilateral amygdala volume reduction was observed for patients with right and left TLE. No gender effect on amygdala volume was observed. Contralateral amygdalar asymmetry was observed for patients with right and left TLE. Although no gender effect was observed on amygdala volume, ipsilateral amygdala volume reductions in patients with TLE might be related to differential rates of cerebral maturation between hemispheres. (C) 2010 Elsevier Inc. All rights reserved.
Keywords Temporal lobe epilepsy
Mesial temporal lobe sclerosis
Magnetic resonance imaging
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Date 2010-11-01
Published in Epilepsy & Behavior. San Diego: Academic Press Inc Elsevier Science, v. 19, n. 3, p. 501-503, 2010.
ISSN 1525-5050 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 501-503
Origin http://dx.doi.org/10.1016/j.yebeh.2010.08.031
Access rights Closed access
Type Article
Web of Science ID WOS:000285451600052
URI http://repositorio.unifesp.br/handle/11600/33055

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