Effect of 6-month nutritional intervention on non-alcoholic fatty liver disease

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dc.contributor.author Elias, Maria Cristina [UNIFESP]
dc.contributor.author Parise, Edison Roberto [UNIFESP]
dc.contributor.author Carvalho, Luciana de [UNIFESP]
dc.contributor.author Szejnfeld, Denis [UNIFESP]
dc.contributor.author Netto, Joao Prola [UNIFESP]
dc.date.accessioned 2016-01-24T14:05:39Z
dc.date.available 2016-01-24T14:05:39Z
dc.date.issued 2010-11-01
dc.identifier http://dx.doi.org/10.1016/j.nut.2009.09.001
dc.identifier.citation Nutrition. New York: Elsevier B.V., v. 26, n. 11-12, p. 1094-1099, 2010.
dc.identifier.issn 0899-9007
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/33047
dc.description.abstract Objective: We evaluated the effect of diet therapy as exclusive treatment on insulin resistance, biochemical parameters of metabolic syndrome, and degree of hepatic steatosis in patients with non-alcoholic fatty liver disease.Methods: Thirty-one patients with non-alcoholic fatty liver disease received a diet with a reduction of 500 to 1000 cal/d, containing 15% protein, 55% carbohydrates, and 30% fat, for 6 mo. At entry and 6 mo after dietary instructions, degrees of hepatic steatosis and visceral obesity were assessed by computed tomography: serum aspartate aminotransferase, alanine aminotransferase, gamma-glutamyl transferase, glucose, triacylglycerols, and high-density lipoprotein cholesterol were measured by automated methods. Body mass index, waist circumference, waist-to-hip ratio, and food intake (7-d diary) were also evaluated. At the end of follow-up, the patients were classified as adherent or non-adherent to treatment according to a weight loss of more or less than 5% of initial body weight, respectively.Results: Seventeen patients were classified as adherent (group 1) and 14 as non-adherent (group 2). Group 2 only presented a significant reduction in body mass index and waist circumference. in contrast, in group 1, in addition to significant improvement of all anthropometric parameters, a significant reduction was observed in alanine aminotransferase and gamma-glutamyl transferase levels, homeostasis model assessment for insulin resistance, visceral fat and tomographic liver density, together with an increase in serum high-density lipoprotein cholesterol levels. These patients presented a significant decrease in total energy intake and in total and saturated fats.Conclusion: Nutritional intervention as exclusive treatment, with a loss of at least 5% of initial weight, is effective in the treatment of non-alcoholic fatty liver disease. (C) 2010 Elsevier Inc. All rights reserved. en
dc.description.sponsorship Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.format.extent 1094-1099
dc.language.iso eng
dc.publisher Elsevier B.V.
dc.relation.ispartof Nutrition
dc.rights Acesso restrito
dc.subject Insulin resistance en
dc.subject Non-alcoholic fatty liver disease en
dc.subject Non-alcoholic steatohepatitis en
dc.subject Obesity en
dc.subject Diet en
dc.subject Waist circumference en
dc.title Effect of 6-month nutritional intervention on non-alcoholic fatty liver disease en
dc.type Artigo
dc.rights.license http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Universidade Federal de São Paulo, Dept Med, Div Gastroenterol & Hepatol, São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Dept Diagnost Image, Abdominal Div, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Med, Div Gastroenterol & Hepatol, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Diagnost Image, Abdominal Div, São Paulo, Brazil
dc.identifier.doi 10.1016/j.nut.2009.09.001
dc.description.source Web of Science
dc.identifier.wos WOS:000283569200012



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