Neonatal arthritis disturbs sleep and behaviour of adult rat offspring and their dams

Neonatal arthritis disturbs sleep and behaviour of adult rat offspring and their dams

Author Roizenblatt, Suely Autor UNIFESP Google Scholar
Andersen, Monica L. Autor UNIFESP Google Scholar
Bignotto, Magda Autor UNIFESP Google Scholar
D'Almeida, Vania Autor UNIFESP Google Scholar
Martins, Paulo J. F. Autor UNIFESP Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract This study aims to evaluate the impact of neonatal arthritis on adult pain threshold, sleep and general behaviours in rats and their lactating dams. Male pups were injected in the hind paw with complete Freund's adjuvant or saline on postnatal day (PN) 1. After weaning, dams were tested for anxiety, sleep recording or hormone profiling (ACTH, corticosterone and prolactin) and brain sampling (pineal melatonin and hippocampus serotonin). At adulthood (PN90), distinct subgroups of neonatal arthritic (AR) and control rats (CR) were also assessed for anxiety and pain thresholds, sleep recording, and blood/brain sampling. Compared to their respective controls at PN12, dams of arthritic rats (DAR) showed a longer latency in expressing pup retrieval and dam-pup interaction. DAR and AR showed a lower pain threshold, anxiety-like behaviour, and sleep fragmentation. Compared to controls, DAR displayed longer sleep latency, reduced paradoxical sleep latency and sleep efficiency, a decrease in prolactin and serotonin levels and increased melatonin levels. This model of unilateral hindpaw inflammation has a wide range of long-term effects in both lactating dams and their adult offspring. (C) 2010 European Federation of International Association for the Study of Pain Chapters. Published by Elsevier B.V. All rights reserved.
Keywords Maternal behaviour
Pain
Sleep
Prolactin
Corticosterone
EEG
Anxiety
Hot plate
Serotonin
Arthritis
Language English
Sponsor AFIP
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Grant number FAPESP: 98/14303-3
Date 2010-11-01
Published in European Journal of Pain. Oxford: Elsevier B.V., v. 14, n. 10, p. 985-991, 2010.
ISSN 1090-3801 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 985-991
Origin http://dx.doi.org/10.1016/j.ejpain.2010.03.008
Access rights Closed access
Type Article
Web of Science ID WOS:000284061900002
URI http://repositorio.unifesp.br/handle/11600/33038

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