International prevalence of recurrent wheezing during the first year of life: variability, treatment patterns and use of health resources

International prevalence of recurrent wheezing during the first year of life: variability, treatment patterns and use of health resources

Author Mallol, Javier Google Scholar
Garcia-Marcos, Luis Google Scholar
Sole, Dirceu Autor UNIFESP Google Scholar
Brand, Paul Google Scholar
EISL Study Grp Google Scholar
Institution Univ Santiago Chile USACH
Univ Murcia
Universidade Federal de São Paulo (UNIFESP)
Isala Clin
Abstract Background Recurrent wheezing (RW) during the first year of life is a major cause of respiratory morbidity worldwide, yet there are no studies on its prevalence at an international level. A study was undertaken to determine the prevalence of RW in infants during their first year of life in affluent and non-affluent localities.Methods This international population-based study was performed in random samples of infants aged 12-15 months from 17 centres in Latin America and Europe. It uses a validated questionnaire answered by parents at the primary care health clinics where infants attend for growth/development monitoring and/or vaccine administration.Results Among the 30 093 infants surveyed, 45.2% (95% CI 44.7% to 45.8%) had at least one episode of wheezing and 20.3% (95% CI 19.8% to 20.7%) had RW. the mean prevalence of RW in Latin American and European centres was 21.4% (95% CI 20.9% to 21.9%) and 15.0% (95% CI 14.0% to 15.9%), respectively (p<0.001). There was significant morbidity associated with RW in terms of severe episodes (59.4%), visits to the emergency department (71.1%) and hospital admissions (26.8%); 46.1% used inhaled corticosteroids.Conclusions the prevalence of RW in infants during the first year of life is high and varies between localities. A significant proportion of infants progress to a more severe condition which results in high use of health resources (visits to emergency department and hospitalisations). the prevalence of RW is lower and less severe in European than in Latin American centres, suggesting there is a higher risk for the disease in developing areas.
Language English
Date 2010-11-01
Published in Thorax. London: B M J Publishing Group, v. 65, n. 11, p. 1004-1009, 2010.
ISSN 0040-6376 (Sherpa/Romeo, impact factor)
Publisher B M J Publishing Group
Extent 1004-1009
Origin http://dx.doi.org/10.1136/thx.2009.115188
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000283258800013
URI http://repositorio.unifesp.br/handle/11600/33010

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