OCT4 gonadal gene expression related to the presence of Y-chromosome sequences in Turner syndrome

OCT4 gonadal gene expression related to the presence of Y-chromosome sequences in Turner syndrome

Author Bianco, Bianca Autor UNIFESP Google Scholar
Oliveira, Kelly Cristina de Autor UNIFESP Google Scholar
Guedes, Alexis D. Autor UNIFESP Google Scholar
Barbosa, Caio P. Google Scholar
Lipay, Monica V. N. Autor UNIFESP Google Scholar
Verreschi, Ieda T. N. Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
ABC Sch Med
Abstract To show that in the dysgenetic gonads of 104 Turner syndrome patients no significant difference was found regarding the expression of the genes DAX1, FOG2, GATA4, OCT4, SF1, SRY, TSPY, WT1, and STRA8 compared with controls, except for genes OCT4, SRY, and TSPY in both gonads of a patient whose chromosomal constitution was 45,X/45,X,add(15)(p11). the expression analysis of genes OCT4, SRY, and TSPY in the dysgenetic gonads of Turner syndrome patients may allow introducing modifications in the microenvironment that could contributed to a malignant transformation process. (Fertil Steril (R) 2010;94:2347-9. (C) 2010 by American Society for Reproductive Medicine.)
Keywords Turner syndrome
gonadal dysgenesis
OCT4 gene
SRY gene
TSPY gene
Y-chromosome
Language English
Date 2010-11-01
Published in Fertility and Sterility. New York: Elsevier B.V., v. 94, n. 6, p. 2347-2349, 2010.
ISSN 0015-0282 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 2347-2349
Origin http://dx.doi.org/10.1016/j.fertnstert.2010.02.036
Access rights Open access Open Access
Type Editorial
Web of Science ID WOS:000283441400090
URI http://repositorio.unifesp.br/handle/11600/33004

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