Identification of an Atypical Strain of Toxoplasma gondii as the Cause of a Waterborne Outbreak of Toxoplasmosis in Santa Isabel do Ivai, Brazil

Identification of an Atypical Strain of Toxoplasma gondii as the Cause of a Waterborne Outbreak of Toxoplasmosis in Santa Isabel do Ivai, Brazil

Author Vaudaux, Jean D. Google Scholar
Muccioli, Cristina Autor UNIFESP Google Scholar
James, Erick R. Google Scholar
Silveira, Claudio Autor UNIFESP Google Scholar
Magargal, Spencer L. Google Scholar
Jung, Calvin Google Scholar
Dubey, J. P. Google Scholar
Jones, Jeffrey L. Google Scholar
Doymaz, Mehmet Z. Google Scholar
Bruckner, David A. Google Scholar
Belfort, Rubens Junior Autor UNIFESP Google Scholar
Holland, Gary N. Google Scholar
Grigg, Michael E. Google Scholar
Institution NIAID
Univ Calif Los Angeles
ARS
United States Ctr Dis Control & Prevent
Universidade Federal de São Paulo (UNIFESP)
Univ British Columbia
Abstract Multilocus DNA sequencing has identified a nonarchetypal strain of Toxoplasma gondii as the causal agent of a waterborne outbreak in Brazil in 2001. the strain, isolated from a water supply epidemiologically linked to the outbreak, was virulent to mice, and it has previously been identified as BrI. Using a serologic assay that detects strain-specific antibodies, we found that 13 (65%) of 20 individuals who were immunoglobulin (Ig) M positive during the outbreak possessed the same serotype as mice infected with the purported epidemic strain. the remaining 7 individuals, plus additional IgM-negative, IgG-positive individuals, possessed 1 of 4 novel serotypes, the most common of which matched the serotype of mice infected with strains isolated from chickens foraging near the outbreak site. the latter strains likely reflect the genetic diversity of T. gondii circulating in highly endemic regions of Brazil. the serotyping assay proved a useful tool for identification of specific individuals infected with the outbreak agent.
Language English
Sponsor National Institutes of Health
National Institute of Allergy and Infectious Diseases
US Department of Agriculture
US Centers for Disease Control and Prevention
Fonds National Suisse pour la Recherche Scientifique
Research to Prevent Blindness (RPB)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Skirball Foundation
Jack H. Skirball Endowed Professorship
Grant number National Institute of Allergy and Infectious Diseases: AI001018
US Department of Agriculture: 1265-32000-076
Fonds National Suisse pour la Recherche Scientifique: PBLA33102339
Date 2010-10-15
Published in Journal of Infectious Diseases. Oxford: Oxford Univ Press, v. 202, n. 8, p. 1226-1233, 2010.
ISSN 0022-1899 (Sherpa/Romeo, impact factor)
Publisher Oxford Univ Press
Extent 1226-1233
Origin http://dx.doi.org/10.1086/656397
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000288250900012
URI http://repositorio.unifesp.br/handle/11600/32990

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