Comparison of the Effects of Electrical Field Stimulation and Low-Level Laser Therapy on Bone Loss in Spinal Cord-Injured Rats

Comparison of the Effects of Electrical Field Stimulation and Low-Level Laser Therapy on Bone Loss in Spinal Cord-Injured Rats

Author Medalha, Carla Christina Autor UNIFESP Google Scholar
Amorim, Beatriz Oliveira Google Scholar
Ferreira, Jessica Mayra Google Scholar
Oliveira, Poliani Google Scholar
Rodrigues Pereira, Rosa Maria Google Scholar
Tim, Carla Autor UNIFESP Google Scholar
Lirani-Galvão, Ana Paula Rebucci Autor UNIFESP Google Scholar
Silva, Orivaldo Lopes da Google Scholar
Renno, Ana Claudia Muniz Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Universidade Federal de São Carlos (UFSCar)
Universidade de São Paulo (USP)
Abstract Objective: This study investigated the effects of low-level laser therapy (LLLT) and electrical stimulation (ES) on bone loss in spinal cord-injured rats. Materials and Methods: Thirty-seven male Wistar rats were divided into four groups: standard control group (CG); spinal cord-injured control (SC); spinal cord-injured treated with laser (SCL; GaAlAs, 830 nm, CW, 30mW/cm, 250 J/cm(2)); and spinal cord-injured treated with electrical field stimulation (SCE; 1.5 MHz, 1: 4 duty cycles, 30 mW, 20 min). Biomechanical, densitometric, and morphometric analyses were performed. Results: SC rats showed a significant decrease in bone mass, biomechanical properties, and morphometric parameters (versus CG). SCE rats showed significantly higher values of inner diameter and internal and external areas of tibia diaphyses; and the SCL group showed a trend toward the same result (versus SC). No increase was found in either mechanical or densitometric parameters. Conclusion: We conclude that the mentioned treatments were able to initiate a positive bone-tissue response, maybe through stimulation of osteoblasts, which was able to determine the observed morphometric modifications. However, the evoked tissue response could not determine either biomechanical or densitometric modifications.
Language English
Date 2010-10-01
Published in Photomedicine and Laser Surgery. New Rochelle: Mary Ann Liebert Inc, v. 28, n. 5, p. 669-674, 2010.
ISSN 1549-5418 (Sherpa/Romeo, impact factor)
Publisher Mary Ann Liebert Inc
Extent 669-674
Origin https://dx.doi.org/10.1089/pho.2009.2691
Access rights Closed access
Type Article
Web of Science ID WOS:000283252800015
URI https://repositorio.unifesp.br/handle/11600/32966

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