Chronic kidney disease in pregnancy requiring first-time dialysis

Chronic kidney disease in pregnancy requiring first-time dialysis

Author Sato, Jussara L. Autor UNIFESP Google Scholar
De Oliveira, Leandro Autor UNIFESP Google Scholar
Kirsztajn, Gianna M. Autor UNIFESP Google Scholar
Sass, Nelson Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Objective: To report on the treatment and outcome of pregnancy in 29 women with chronic kidney disease (CKD), 24 of whom had moderate or severe renal dysfunction. Methods: Renal dysfunction at the onset of pregnancy was stratified: serum creatinine <= 1.4 mg/dL was defined as mild; 1.5-2.5 mg/dL was defined as moderate; and >2.5 mg/dL was defined as severe renal insufficiency. Clinical complications and perinatal outcomes were evaluated. Results: the average serum creatinine level at the beginning of pregnancy was 3.32 mg/dL (range, 1.2-7.1 mg/dL), and the average urine protein level was 1.51 g in 24 hours (range, 0.1-5.6 g in 24 hours). Dialysis therapy was necessary for 1 woman with mild renal dysfunction, 4 patients with moderate renal dysfunction, and 17 patients with severe renal dysfunction. Conclusion: the use of dialysis in pregnancy among women with moderate or severe renal dysfunction proved to be useful, but many patients became dependent on dialysis. It is not known whether this was due to the interaction between pregnancy and advanced CKD. (C) 2010 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.
Keywords Chronic kidney disease
Dialysis
Pregnancy
Language English
Date 2010-10-01
Published in International Journal of Gynecology & Obstetrics. Clare: Elsevier B.V., v. 111, n. 1, p. 45-48, 2010.
ISSN 0020-7292 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 45-48
Origin http://dx.doi.org/10.1016/j.ijgo.2010.04.029
Access rights Closed access
Type Article
Web of Science ID WOS:000282735100011
URI http://repositorio.unifesp.br/handle/11600/32955

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