Seizures during pregnancy modify the development of hippocampal interneurons of the offspring

Seizures during pregnancy modify the development of hippocampal interneurons of the offspring

Author Vale, Tiago Gurgel do Autor UNIFESP Google Scholar
Silva, Alexandre Valotta da Autor UNIFESP Google Scholar
Lima, Daiana Correia Autor UNIFESP Google Scholar
Lima, Eliangela de Autor UNIFESP Google Scholar
Torres, Laila Brito Autor UNIFESP Google Scholar
Cossa, Ana Carolina Autor UNIFESP Google Scholar
Oliveira, Elaine Menezes de Autor UNIFESP Google Scholar
Cabral, Francisco Romero Google Scholar
Cavalheiro, Esper Abrao Autor UNIFESP Google Scholar
Naffah-Mazzacoratti, Maria da Graca Autor UNIFESP Google Scholar
Amado, Debora Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Ctr Nacl Primatas
Hosp Albert Einstein
Abstract We investigated the effect of epileptic seizures during pregnancy on hippocampal expression of calcium-binding proteins in the offspring. Female Wistar rats were submitted to the pilocarpine model and mated during the chronic period. Seizure frequency was monitored over the entire pregnancy. Pups were perfused at postnatal days 6 and 13. and the brains processed for Nissl staining and immunohistochemistry for NeuN, calbindin, calretinin, and parvalbumin. Number of stained cells in the hippocampus was estimated through stereological methods. Our results showed a decrease in epileptic seizure frequency during pregnancy. No differences were observed in NeuN-positive. CR-positive cells, and Nissl-stained hippocampal neurons between the groups. However, there was a significant decrease in calbindin-positive cells (P=0.005) and a significant increase in parvalbumin-positive cells (P=0.02) in the experimental group when compared with the control group. These results suggest that seizures during pregnancy affect the development of specific hippocampal interneurons of the offspring. (C) 2010 Elsevier Inc. All rights reserved.
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Date 2010-09-01
Published in Epilepsy & Behavior. San Diego: Academic Press Inc Elsevier Science, v. 19, n. 1, p. 20-25, 2010.
ISSN 1525-5050 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 20-25
Access rights Closed access
Type Article
Web of Science ID WOS:000282395800004

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