Anterior thalamus deep brain stimulation at high current impairs memory in rats

Anterior thalamus deep brain stimulation at high current impairs memory in rats

Author Hamani, Clement Autor UNIFESP Google Scholar
Dubiela, Francisco Paulino Autor UNIFESP Google Scholar
Soares, Juliana C. K. Autor UNIFESP Google Scholar
Shin, Damian Google Scholar
Bittencourt, Simone Autor UNIFESP Google Scholar
Covolan, Luciene Autor UNIFESP Google Scholar
Carlen, Peter L. Google Scholar
Laxton, Adrian W. Google Scholar
Hodaie, Mojgan Google Scholar
Stone, Scellig S. D. Google Scholar
Ha, Yoon Google Scholar
Hutchison, William D. Google Scholar
Lozano, Andres M. Google Scholar
Mello, Luiz E. Autor UNIFESP Google Scholar
Oliveira, Maria Gabriela M. Autor UNIFESP Google Scholar
Institution Toronto Western Hosp
Universidade Federal de São Paulo (UNIFESP)
Abstract Deep brain stimulation (DBS) of the anterior thalamic nucleus (AN), an important relay in the circuitry of memory, is currently being proposed as a treatment for epilepsy. Despite the encouraging results with the use of this therapy, potential benefits and adverse effects are yet to be determined. we show that AN stimulation at relatively high current disrupted the acquisition of contextual fear conditioning and impaired performance on a spatial alternating task in rats. This has not been observed at parameters generating a charge density that approximated the one used in clinical practice. At settings that impaired behavior, AN stimulation induced a functional depolarization block nearby the electrode, increased c-Fos expression in cerebral regions projecting to and receiving projections from the AN, and influenced hippocampal activity. This suggests that complex mechanisms might be involved in the effects of AN DBS, including a local target inactivation and the modulation of structures at a distance. Though translating data from animals to humans has to be considered with caution, our study underscores the need for carefully monitoring memory function while selecting stimulation parameters during the clinical evaluation of AN DBS. (C) 2010 Elsevier Inc. All rights reserved.
Keywords Anterior nucleus
Thalamus
Memory
Epilepsy
Deep brain stimulation
Hippocampus
Adverse effects
Language English
Date 2010-09-01
Published in Experimental Neurology. San Diego: Academic Press Inc Elsevier Science, v. 225, n. 1, p. 154-162, 2010.
ISSN 0014-4886 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 154-162
Origin http://dx.doi.org/10.1016/j.expneurol.2010.06.007
Access rights Closed access
Type Article
Web of Science ID WOS:000281339300021
URI http://repositorio.unifesp.br/handle/11600/32874

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