Long-term efficacy of rituximab in hepatitis C virus-associated cryoglobulinemia

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dc.contributor.author Pereira, Patrícia da Silva Fucuta [UNIFESP]
dc.contributor.author Lemos, Lara Barros [UNIFESP]
dc.contributor.author Oliveira Uehara, Silvia Naomi de [UNIFESP]
dc.contributor.author Souza e Silva, Ivonete Sandra de [UNIFESP]
dc.contributor.author Benedito Silva, Antonio Eduardo [UNIFESP]
dc.contributor.author Ferraz, Maria Lucia Cardoso Gomes [UNIFESP]
dc.date.accessioned 2016-01-24T14:05:24Z
dc.date.available 2016-01-24T14:05:24Z
dc.date.issued 2010-09-01
dc.identifier http://dx.doi.org/10.1007/s00296-009-1106-1
dc.identifier.citation Rheumatology International. Heidelberg: Springer Heidelberg, v. 30, n. 11, p. 1515-1518, 2010.
dc.identifier.issn 0172-8172
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/32864
dc.description.abstract Mixed cryoglobulinemia is one of the most closely related extrahepatic manifestations of hepatitis C virus and requires a challenging therapeutic approach depending on the severity of the symptoms. Here, we describe the long-term follow-up of a patient with important cutaneous, articular and neural manifestations of cryoglobulinemia associated with chronic hepatitis C treated with rituximab. A 42-year-old woman who did not respond to previous interferon-based treatments (standard and pegylated interferon plus ribavirin) and corticosteroids was subjected to treatment with rituximab at a dose of 375 mg/mA(2) per week for 4 consecutive weeks. the drug was well tolerated and complete improvement of arthralgia was immediately evident. There was gradual improvement of lower limbs paresthesia and healing of a leg ulcer that had been active for 5 years. the clinical and immunological responses induced by rituximab are sustained over long-term follow-up, and this case illustrates the drug efficacy for non-responder patients to antiviral therapy. en
dc.format.extent 1515-1518
dc.language.iso eng
dc.publisher Springer
dc.relation.ispartof Rheumatology International
dc.rights Acesso restrito
dc.subject Cryoglobulinemia en
dc.subject Hepatitis C virus en
dc.subject Rituximab en
dc.subject Vasculitis en
dc.title Long-term efficacy of rituximab in hepatitis C virus-associated cryoglobulinemia en
dc.type Artigo
dc.rights.license http://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Universidade Federal de São Paulo, Div Gastroenterol, Hepatitis Sect, BR-04023900 São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Div Gastroenterol, Hepatitis Sect, BR-04023900 São Paulo, Brazil
dc.identifier.doi 10.1007/s00296-009-1106-1
dc.description.source Web of Science
dc.identifier.wos WOS:000281254400019



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