Bone Deposition, Bone Resorption, and Osteosarcoma

Bone Deposition, Bone Resorption, and Osteosarcoma

Author Toledo, Silvia Regina Caminada de Autor UNIFESP Google Scholar
Oliveira, Indhira Dias Autor UNIFESP Google Scholar
Okamoto, Oswaldo Keith Autor UNIFESP Google Scholar
Zago, Marco Antonio Google Scholar
Alves, Maria Teresa de Seixas Autor UNIFESP Google Scholar
Garcia Filho, Reynaldo Jesus Autor UNIFESP Google Scholar
Macedo, Carla Renata Donato Pacheco Autor UNIFESP Google Scholar
Petrilli, Antonio Sergio Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Abstract Bone deposition and bone resorption are ongoing dynamic processes, constituting bone remodeling. Some bone tumors, such as osteosarcoma (OS), stimulate focal bone deposition. OS is the most common primary bone tumor in children and young adults. A complex network of genes regulates bone remodeling and alterations in its expression levels can influence the genesis and progression of bone diseases, including OS. We hypothesized that the expression profiles of bone remodeling regulator genes would be correlated with OS biology and clinical features. We used real-time PCR to evaluate the mRNA levels of the tartrate-resistant acid phosphatase (ACP5), colony stimulating factor-1 (CSF1R), bone morphogenetic protein 7 (BMP7), collagen, type XI, alpha 2 (COL11A2), and protein tyrosine phosphatases zeta 1 (PTPRZ1) genes, in 30 OS tumor samples and correlated with clinical and histological data. All genes analyzed, except CSF1R, were differentially expressed when compared with normal bone expression profiles. in our results, OS patients with high levels of COL11A2 mRNA showed worse overall (p = 0.041) and event free survival (p = 0.037). Also, a trend for better overall survival was observed in patients with samples showing higher expression of BMP7 (p =0.067). COL11A2 overexpression and BMP7 underexpression could collaborate to OS tumor growth, through its central role in bone remodeling process. (C) 2010 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 28:1142-1148, 2010
Keywords osteosarcoma
bone remodeling
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
GRAACC (Grupo de Apoio ao Adolescente e Crianca corn Cancer)
Grant number FAPESP: 04/12150-8
FAPESP: 07/53869-3
Date 2010-09-01
Published in Journal of Orthopaedic Research. Hoboken: John Wiley & Sons Inc, v. 28, n. 9, p. 1142-1148, 2010.
ISSN 0736-0266 (Sherpa/Romeo, impact factor)
Publisher Wiley-Blackwell
Extent 1142-1148
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000280897100005

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