Metabolic differences between male and female adolescents with non-alcoholic fatty liver disease, as detected by ultrasound

Metabolic differences between male and female adolescents with non-alcoholic fatty liver disease, as detected by ultrasound

Author Fernandes, M. T. B. Autor UNIFESP Google Scholar
Ferraro, A. A. Google Scholar
Azevedo, R. A. de Autor UNIFESP Google Scholar
Fagundes Neto, U. Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Abstract Background:Age, developmental stage and gender are risk factors for paediatric non-alcoholic fatty liver disease (NAFLD).Aims:The aim of this study was to identify differences in clinical or laboratory variables between sexes in adolescents with NAFLD.Methodology:Ninety obese adolescents including 36 males and 54 females were evaluated. Inclusion criteria for this study were a Body Mass Index above the 95th percentile, as set forth by the National Center for Health Statistics, and an age of 10-19 years. A clinical and laboratory evaluation was conducted for all adolescents.Results:The variables that were found to be predictive of NAFLD in adolescence were visceral fat, Aminotransferase, Gamma-Glutamyl Transferase, triglyderides, cholesterol and LDL-cholesterol. We also observed that cholesterol and LDL-cholesterol variables were influenced by gender, i.e. there was a significant statistical difference in the values of these variables between male and female adolescents. With regard to cholesterol serum concentrations, the risk was 6.99 times greater for females, compared with 1.2 times for males; and for LDL-cholesterol serum concentrations the risk was 8.15 times greater for females, compared with and 1.26 times for males.Conclusion:Female adolescents with NAFLD showed a significantly different metabolic behaviour than males.
Keywords Developmental stage
Gender
Non-alcoholic fatty liver disease
Paediatrics
Language English
Date 2010-08-01
Published in Acta Paediatrica. Malden: Wiley-Blackwell, v. 99, n. 8, p. 1218-1223, 2010.
ISSN 0803-5253 (Sherpa/Romeo, impact factor)
Publisher Wiley-Blackwell
Extent 1218-1223
Origin http://dx.doi.org/10.1111/j.1651-2227.2010.01774.x
Access rights Closed access
Type Article
Web of Science ID WOS:000279438000022
URI http://repositorio.unifesp.br/handle/11600/32806

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