Cytokine and hormonal profile in serum samples of patients undergoing controlled ovarian stimulation: interleukin-1 beta predicts ongoing pregnancy

Cytokine and hormonal profile in serum samples of patients undergoing controlled ovarian stimulation: interleukin-1 beta predicts ongoing pregnancy

Author Bonetti, Tatiana Carvalho de Souza Autor UNIFESP Google Scholar
Salomao, Reinaldo Autor UNIFESP Google Scholar
Brunialti, Milena Karina Coló Autor UNIFESP Google Scholar
Braga, D. P. A. F. Google Scholar
Borges Júnior, Edson Autor UNIFESP Google Scholar
Silva, Ismael Dale Cotrim Guerreiro da Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Fertil Assisted Fertilizat Ctr
Abstract Changes in the endometrium are not regulated exclusively by ovarian hormones; the immune system has also been implicated in normal endometrial function, similar to processes taking place during inflammatory and reparative path. Many cytokines are crucially important for reproductive processes, and the role of cytokines in the female reproductive system function has been broadly investigated during controlled ovarian stimulation (COS) for IVF attempts. the aim of this study was to evaluate the levels of serum cytokines and hormones, and the clinical outcomes of women who underwent COS and ICSI procedures.The study prospectively included 96 patients (aged 22-43 years, unexplained or male infertility, n = 61; female infertility factors, n = 35) who underwent ICSI cycles. Serum levels of interleukin (IL-8, IL-6, IL-1 beta, IL-10, IL-12), tumour necrosis factor and leukaemia-inhibitory factor (LIF) and the hormones FSH, estradiol, progesterone, anti-Mullerian hormone and Inhibin-B were measured on the day of oocyte retrieval.The ongoing pregnancy rate was 25.3%. the presence of serum IL-1 beta positively affected the implantation rate (P = 0.004) and increased the chance of becoming pregnant by 15 fold. Furthermore, the percentage of patients with detectable serum IL-1 beta levels who conceived (62.5%) was higher than those who failed to conceive (37.5%; P = 0.019). the LIF was undetectable in all serum samples, and no other factors influenced the clinical outcomes of patients undergoing ICSI cycles.Our findings revealed that detectable serum levels of IL-1 beta on the day of oocyte retrieval in patients undergoing COS and ICSI are predictive of successful implantation and ongoing pregnancy.
Keywords ICSI
implantation
cytokines
interleukin-1 beta
oocyte retrieval
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Grant number FAPESP: 2007/58467-0
CNPq: 579224/2008-2
Date 2010-08-01
Published in Human Reproduction. Oxford: Oxford Univ Press, v. 25, n. 8, p. 2101-2106, 2010.
ISSN 0268-1161 (Sherpa/Romeo, impact factor)
Publisher Oxford Univ Press
Extent 2101-2106
Origin http://dx.doi.org/10.1093/humrep/deq171
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000280280500030
URI http://repositorio.unifesp.br/handle/11600/32741

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