Influence of Progesterone on Sexual Performance in Male Rats

Influence of Progesterone on Sexual Performance in Male Rats

Author Alvarenga, Tathiana A. Autor UNIFESP Google Scholar
Andersen, Monica L. Autor UNIFESP Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Introduction.It has been documented that copulatory experience can alter or improve sexual performance in male rats. However, the hormonal basis and the number of sexual encounters needed for a rat to acquire sufficient performance remains unclear.Aim.The aim of this study was to examine whether levels of testosterone and progesterone are associated with sexual performance in male rats.Methods.Adult male Wistar Hannover rats were exposed to a receptive female for 15 minutes every other day for 9 days for acquiring sexual experience.Main Outcome Measures.After training protocol, rats were scored as low or high sexual performers. Hormonal levels (testosterone and progesterone) were evaluated in both trained and non-trained control groups.Results.Our results showed that a 9-day training period was not sufficient for some male rats to acquire a good level of sexual performance. While 42.5% of the rats displayed excellent sexual performance during the training sessions, 17.5% showed adequate performance, 7.5% had low sexual activity, and 32.5% of the rats did not display any sexual behaviors whatsoever. Additionally, after 4 days of training, rats with excellent/adequate performance showed a significant decrease in ejaculation latency relative to the first day of training. the rats with low or no sexual activity had lower progesterone levels relative to those displaying the highest sexual performance after 9 days of training. Testosterone, in turn, was also significantly reduced in animals with low/no sexual performance compared with excellent/adequate rats.Conclusion.In conclusion, progesterone may be a limiting factor to promoting sexual performance in male rats. Alvarenga TA, Andersen ML, and Tufik S. Influence of progesterone on sexual performance in male rats. J Sex Med 2010;7:2435-2444.
Keywords Sexual Experience
Sexual Behavior
Testosterone
Progesterone
Ejaculation
Hormones
Sexual Function in Animal Model
Male Rat
Language English
Sponsor Associacao Fundo de Incentivo a Psicofarmacologia (AFIP)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Grant number FAPESP: 98/14303-3
FAPESP: 09/01030-5
Date 2010-07-01
Published in Journal of Sexual Medicine. Malden: Wiley-Blackwell, v. 7, n. 7, p. 2435-2444, 2010.
ISSN 1743-6095 (Sherpa/Romeo, impact factor)
Publisher Wiley-Blackwell
Extent 2435-2444
Origin http://dx.doi.org/10.1111/j.1743-6109.2010.01851.x
Access rights Closed access
Type Article
Web of Science ID WOS:000279620100014
URI http://repositorio.unifesp.br/handle/11600/32710

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