Humoral and Cellular Immune Responses to Measles and Tetanus: the Importance of Elapsed Time Since Last Exposure and the Nature of the Antigen

Humoral and Cellular Immune Responses to Measles and Tetanus: the Importance of Elapsed Time Since Last Exposure and the Nature of the Antigen

Author Viana, Patricia O. Autor UNIFESP Google Scholar
Ono, Erika Autor UNIFESP Google Scholar
Miyamoto, Maristela Autor UNIFESP Google Scholar
Salomao, Reinaldo Autor UNIFESP Google Scholar
Costa-Carvalho, Beatriz T. Autor UNIFESP Google Scholar
Weckx, Lily Y. Autor UNIFESP Google Scholar
Moraes-Pinto, Maria Isabel de Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract This study aims to assess the cellular and humoral immune response pre- and post-vaccine rechallenge in healthy adults with previous exposure to measles (virus or vaccine) and different time intervals since last tetanus vaccine.Humoral immunity was tested by ELISA, and cellular immunity was tested by intracellular interferon gamma detection after in vitro stimulation with antigens.While cellular immunity was comparable among vaccinated individuals and those who had measles, higher antibody levels were found in those who had the disease in the past. Both antibodies and CD4(+) T cell tetanus immune responses depended on elapsed time since last immunization. Following a vaccine booster, an increase in cellular immunity and antibodies was observed to both tetanus and measles. Measles humoral response was much more intense among individuals previously exposed to a wild virus.In an era when natural boosters are less frequent, an immune surveillance might be necessary to investigate waning immunity as occurs for tetanus.
Keywords Measles
tetanus
cellular immunity
antibody
immunologic memory
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Grant number FAPESP: 05/57802-5
FAPESP: 05/57571-3
Date 2010-07-01
Published in Journal of Clinical Immunology. New York: Springer/plenum Publishers, v. 30, n. 4, p. 574-582, 2010.
ISSN 0271-9142 (Sherpa/Romeo, impact factor)
Publisher Springer
Extent 574-582
Origin http://dx.doi.org/10.1007/s10875-010-9420-7
Access rights Closed access
Type Article
Web of Science ID WOS:000279683900013
URI http://repositorio.unifesp.br/handle/11600/32671

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