Leukemia, non-Hodgkin's lymphoma, and Wilms tumor in childhood: the role of birth weight

Leukemia, non-Hodgkin's lymphoma, and Wilms tumor in childhood: the role of birth weight

Author Rangel, Marina Autor UNIFESP Google Scholar
Cypriano, Monica Autor UNIFESP Google Scholar
Martino Lee, Maria Lucia de Autor UNIFESP Google Scholar
Vercillo Luisi, Flavio Augusto Autor UNIFESP Google Scholar
Petrilli, Antonio Sergio Autor UNIFESP Google Scholar
Strufaldi, Maria Wany Louzada Autor UNIFESP Google Scholar
Franco, Maria do Carmo Pinho Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Abstract There is emerging evidence that higher birth weight is associated with increased risk of cancer, in particular childhood leukemia. the purpose of this paper is to study whether this correlation is also significant with other childhood cancer. for this, we conducted a case-control study including 410 childhood cancer patients and 1,575 matched controls to investigate birth weight as a risk factor for leukemia, Wilms tumor, and non-Hodgkin's lymphoma. the estimated risk for all cancers has been found to be statistically and significantly higher in birth weight of more than 4,000 g (odds ratio, 2.50 and 95% confidence intervals (CI), 1.72-3.63). for leukemia, the estimated risk was 1.86 (95% CI, 1.04-3.30), for non-Hodgkin lymphoma, 1.99 (95% CI, 1.08-3.69), and being more remarkable for Wilms tumor, 4.76 (95% CI, 2.73-8.28). Moreover, moderate increased risk of both leukemia and non-Hodgkin lymphoma was also associated with birth weight between 3,000 and 3,999 g. High birth weight was associated with all cancers also when adjusted by gestational age, length at birth, and gender (odds ratio, 6.10 and 95% CI, 1.15-32.57). No associations were found for maternal alcohol consumption during pregnancy, maternal smoking, or smoking by other people at home or presence of obstetric variables (e.g., gestational diabetes, preeclampsia, and abruptio placentae). the present study supports the hypothesis that high birth weight is an independent risk factor for childhood Wilms tumor, leukemia, and non-Hodgkin lymphoma. Further studies should explore biological reasons to explain this relationship and, ultimately, to expand our knowledge about prenatal influences on the occurrence of this disease.
Keywords Childhood cancer
Birth weight
Risk factor
Wilms tumor
Leukemia
Non-Hodgkin's lymphoma
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Grant number FAPESP: FAPESP-07/58044-2
FAPESP: FAPESP-2009/51873-9
Date 2010-07-01
Published in European Journal of Pediatrics. New York: Springer, v. 169, n. 7, p. 875-881, 2010.
ISSN 0340-6199 (Sherpa/Romeo, impact factor)
Publisher Springer
Extent 875-881
Origin http://dx.doi.org/10.1007/s00431-010-1139-1
Access rights Closed access
Type Article
Web of Science ID WOS:000278090600016
URI http://repositorio.unifesp.br/handle/11600/32668

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