Higher dopamine transporter density in Parkinson's disease patients with depression

Higher dopamine transporter density in Parkinson's disease patients with depression

Author Felicio, Andre C. Autor UNIFESP Google Scholar
Moriyama, Tais S. Autor UNIFESP Google Scholar
Godeiro-Junior, Clecio Autor UNIFESP Google Scholar
Shih, Ming C. Autor UNIFESP Google Scholar
Hoexter, Marcelo Q. Autor UNIFESP Google Scholar
Borges, Vanderci Autor UNIFESP Google Scholar
Silva, Sonia M. A. Autor UNIFESP Google Scholar
Amaro-Junior, Edson Google Scholar
Andrade, Luiz A. F. Google Scholar
Ferraz, Henrique B. Autor UNIFESP Google Scholar
Bressan, Rodrigo A. Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
HIAE
Abstract Depression is a frequent non-motor symptom in Parkinson's disease (PD) with increasing rates with the progression of the disease. Molecular imaging studies have shown a reduction of dopamine transporter (DAT) density in depressed PD patients (dPD); however, DAT role in the pathophysiology of PD depression is not clear since clinical matching was inappropriate and DAT reduction could be attributed to PD severity.To further examine the role of DAT in PD depression, this study compared thoroughly matched depressed vs. non-depressed PD patients (ndPD).Twenty PD patients (n = 10 ndPD; n = 10 dPD) matched for age and disease severity were submitted to brain SPECT imaging with [(99m)Tc]-TRODAT-1, a DAT radioligand. DAT-binding potential was calculated using regions of interest bilaterally drawn in the striatum, caudate, and putamen. Depression was defined according to Beck Depression Inventory (BDI; cut-off > 18).Mean BDI scores were higher in dPD (25.0 +/- 5.6) than in ndPD patients (8.0 +/- 1.9, p < 0.0001). DAT density was greater on dPD especially in the left caudate (dPD 0.87 +/- 0.19 vs. ndDP 0.69 +/- 0.18, p = 0.02) and right putamen (dPD 0.37 +/- 0.07 vs. ndPD 0.28 +/- 0.13, p = 0.03) than in ndPD patients.Our results suggest that in vivo DAT density is increased in dPD patients as compared to ndPD, suggesting that DAT is implicated in the pathophysiology of PD depression.
Keywords Parkinson's disease (PD)
Depression
SPECT
Dopamine transporter
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Instituto UNIEMP
Date 2010-07-01
Published in Psychopharmacology. New York: Springer, v. 211, n. 1, p. 27-31, 2010.
ISSN 0033-3158 (Sherpa/Romeo, impact factor)
Publisher Springer
Extent 27-31
Origin http://dx.doi.org/10.1007/s00213-010-1867-y
Access rights Closed access
Type Article
Web of Science ID WOS:000278742500003
URI http://repositorio.unifesp.br/handle/11600/32663

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