Impression cytology findings in bullous keratopathy

Impression cytology findings in bullous keratopathy

Author Paris, Fabiana dos Santos Autor UNIFESP Google Scholar
Goncalves, Eliana Domingues Autor UNIFESP Google Scholar
Barros, Jeison de Nadai Autor UNIFESP Google Scholar
Queiroz Campos, Mauro Silveira de Autor UNIFESP Google Scholar
Sato, Elcio Hideo Autor UNIFESP Google Scholar
Gomes, José Álvaro Pereira Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Aim To evaluate, by impression cytology (IC), the cytological features of the central area of corneal epithelial surface of patients with symptomatic bullous keratopathy (BK).Design Cross-sectional observational case series.Methods IC of the central cornea was performed in 72 eyes of 72 patients with symptomatic BK between June 2005 and December 2006. Patients were divided into two groups according to the presence (group GC) or not of goblet cells (group NGC). the diagnosis of limbal stem cell deficiency (LSCD) was defined by the presence of one or more intact goblet cells on the corneal surface. Squamous metaplasia was classified according to Murube and Rivas.Results Epithelial squamous metaplasia was found in 72 (100%) eyes, along with conjunctival goblet cells in 25 (34.72%) eyes. Squamous metaplasia was grade 1 in group GC and more advanced grades in group NGC. Corneal neovascularisation was present in 62 (82.11%) eyes. Vessel measure was more than 4 mm in 11 eyes (23.4%) in group NGC and 10 eyes (40%) in group GC (p=0.559), and they were mostly subepithelial in 23 eyes (48.9%) in group NGC and 12 (48%) eyes in group GC (p=0.822).Conclusion Squamous metaplasia was the most frequent finding associated with advanced BK. the presence of goblet cells on the surface of corneas with squamous metaplasia grade 1, in a significant number of patients, suggests that limbal stem cell deficiency is a common condition associated with advanced cases of BK.
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Grant number FAPESP: Alto da Lapa -CEP 05468-901
Date 2010-06-01
Published in British Journal of Ophthalmology. London: B M J Publishing Group, v. 94, n. 6, p. 773-776, 2010.
ISSN 0007-1161 (Sherpa/Romeo, impact factor)
Publisher B M J Publishing Group
Extent 773-776
Access rights Closed access
Type Article
Web of Science ID WOS:000278093200022

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