Expression of a cell death marker (clusterin) in muscle target fibers

Show simple item record Oliveira, Acary Souza Bulle [UNIFESP] Corbo, Massimo Duigou, Greg Gabbai, Alberto Alain [UNIFESP] Hays, Arthur P. 2015-06-14T13:24:24Z 2015-06-14T13:24:24Z 1993-09-01
dc.identifier.citation Arquivos de Neuro-Psiquiatria. Academia Brasileira de Neurologia - ABNEURO, v. 51, n. 3, p. 371-376, 1993.
dc.identifier.issn 0004-282X
dc.description.abstract We report, for the first time, the expression of immunoractivity to clusterin in skeletal muscle. Clusterin, a protein probably related to the process of programmed cell death (apoptosis), was specifically very highly expressed in target fibers. All target fibers found in 50 muscle biopsy samples from a variety of neuromuscular disorders expressed a high concentration of clusterin in the middle of the targets. Clusterin was not expressed in any targetoid fibers or cores. Acute denervation, where targets are mostly seen, may be the beginning of apoptosis. Hence our findings support the concept that targets are harbingers of acute denervation. en
dc.description.abstract Descrevemos, pela primeira vez, a expressão de imunorreatividade para clusterina em músculo esquelético. Clusterina, proteína relacionada ao processo de morte celular programada (apoptosis), encontrou-se especificamente muito aumentada em fibras musculares com «target» (FT). Todas as FT encontradas em 50 biópsias musculares de pacientes com diferentes doenças neuromusculares apresentaram alta concentração de clusterina no centro das FT. Clusterina não esteve semelhantemente aumentada em fibras com «targetóide» ou com «core». A alta expressão de clusterina em «targets» indica que FT podem ser o início de apoptosis e que há íntima relação entre FT e desnervação aguda. pt
dc.format.extent 371-376
dc.language.iso eng
dc.publisher Academia Brasileira de Neurologia - ABNEURO
dc.relation.ispartof Arquivos de Neuro-Psiquiatria
dc.rights Acesso aberto
dc.subject skeletal muscle en
dc.subject target en
dc.subject clusterin en
dc.subject músculo esquelético pt
dc.subject fibras com «target» pt
dc.subject clusterina pt
dc.title Expression of a cell death marker (clusterin) in muscle target fibers en
dc.title.alternative Expressão de marcador de morte celular programada (apoptosis) em fibras musculares com «target» pt
dc.type Artigo
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Columbia University College of Physicians and Surgeons Department of Neurosurgery
dc.description.affiliation Escola Paulista de Medicina Department of Neurology
dc.description.affiliation Columbia University College of Physicians and Surgeons Department of Neurosurgery
dc.description.affiliationUnifesp UNIFESP, EPM, Department of Neurology
dc.identifier.file S0004-282X1993000300014.pdf
dc.identifier.scielo S0004-282X1993000300014
dc.identifier.doi 10.1590/S0004-282X1993000300014
dc.description.source SciELO


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