Long-term and short-term effects of simulated birth trauma, cesarean and vaginal delivery on sulfated glycosaminoglycans in the urethra of female rats

Long-term and short-term effects of simulated birth trauma, cesarean and vaginal delivery on sulfated glycosaminoglycans in the urethra of female rats

Author Takano, Claudia Cristina Autor UNIFESP Google Scholar
Pinheiro Sobreira Bezerra, Leonardo Robson Autor UNIFESP Google Scholar
Monteiro Zucchi, Eliana Viana Autor UNIFESP Google Scholar
Nader, Helena Bonciani Autor UNIFESP Google Scholar
Ferreira Sartori, Marair Gracio Autor UNIFESP Google Scholar
Batista Castelo Girao, Manoel Joao Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract This study assesses the effects of simulated birth trauma, vaginal and cesarean delivery on glycosaminoglycans in the connective tissue of female rat urethra.One hundred and ten female rats were divided into six groups: A-control, B-vaginal trauma, C-cesarean delivery, D-cesarean delivery followed by vaginal trauma, E-vaginal delivery, and F-female rats on the 20th day of gestation. in each group, half of the animals were sacrificed 4 days after the procedures and half were sacrificed 12 weeks later. Glycosaminoglycans were extracted by proteolysis and analyzed using densitometry after agarose gel electrophoresis.The examination at 4 days showed larger amounts of glycosaminoglycans in pregnant female rats compared to other groups. the examination at 12 weeks showed larger amounts of glycosaminoglycans in the cesarean delivery group followed by simulated birth trauma.There is a change in sulfated glycosaminoglycans in female rat urethra during pregnancy and simulated birth trauma.
Keywords Birth trauma
Glycosaminoglycans
Pregnancy
Language English
Date 2010-06-01
Published in International Urogynecology Journal. London: Springer London Ltd, v. 21, n. 6, p. 705-710, 2010.
ISSN 0937-3462 (Sherpa/Romeo, impact factor)
Publisher Springer
Extent 705-710
Origin http://dx.doi.org/10.1007/s00192-009-1087-3
Access rights Closed access
Type Article
Web of Science ID WOS:000276964000014
URI http://repositorio.unifesp.br/handle/11600/32574

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