The role of nutritional profile in the orexigenic neuropeptide secretion in nonalcoholic fatty liver disease obese adolescents

The role of nutritional profile in the orexigenic neuropeptide secretion in nonalcoholic fatty liver disease obese adolescents

Author Piano, Aline de Autor UNIFESP Google Scholar
Tock, Lian Autor UNIFESP Google Scholar
Carnier, June Autor UNIFESP Google Scholar
Foschini, Denis Autor UNIFESP Google Scholar
Sanches, Priscila de Lima Autor UNIFESP Google Scholar
Correa, Fabiola Alvise Autor UNIFESP Google Scholar
Oyama, Lila Missae Autor UNIFESP Google Scholar
Oller do Nascimento, Claudia Maria Autor UNIFESP Google Scholar
Lederman, Henrique Manoel Autor UNIFESP Google Scholar
Ernandes, Regina Autor UNIFESP Google Scholar
Mello, Marco Tulio de Autor UNIFESP Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Damaso, Ana Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Background Little progress has been made to identify the central neuroendocrine pathway involved in the energy intake control in nonalcoholic fatty liver disease (NAFLD) patients.Objective To assess the influence of orexigenic neuropeptides in the nutritional aspects of NAFLD obese adolescents submitted to a long-term interdisciplinary approach.Methods Fifty adolescents aged 15-19 years, with body mass index at least 95th percentile, consisting of 25 patients without NAFLD and 25 with NAFLD. the NAFLD diagnosis was determined by ultrasonography. Blood samples were collected to analyze glycemia, hepatic transaminases, and lipid profile. Insulin resistance was estimated by Homeostasis Model Assessment Insulin Resistance Index. Neuropeptide Y (NPY) and agouti related protein concentrations were measured by enzyme-linked immunosorbent assay. Analyses of food intake were made by 3 days recordatory inquiry.Results At baseline conditions, the patients with NAFLD had significantly higher values of body mass, body mass index, visceral fat, triglycerides, VLDL-C, and hepatic transaminases. After the long-term intervention, they presented a significant reduction in these parameters. in both the groups, it was observed a significant decrease in energy intake, macronutrients and dietetic cholesterol. Only the patients with NAFLD presented a positive correlation between the saturated fatty acids intake and the orexigenic neuropeptides NPY and agouti related protein, and carbohydrate with NPY. Indeed, it was observed a positive correlation between energy intake, lipid (%) and saturated fatty acids with visceral fat accumulation.Conclusion Our findings showed an important influence of diet composition in the orexigenic system, being essential consider that the excessive saturated fatty acids intake could be a determinant factor to increase nonalcoholic fatty liver disease. Eur J Gastroenterol Hepatol 22:557-563 (C) 2010 Wolters Kluwer Health | Lippincott Williams & Wilkins.
Keywords neuropeptides
nonalcoholic fatty liver disease
Language English
Sponsor AFIP
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Grant number FAPESP: 2008/53069-0
FAPESP: 2006/00684-3
FAPESP: 9814303-3
Date 2010-05-01
Published in European Journal of Gastroenterology & Hepatology. Philadelphia: Lippincott Williams & Wilkins, v. 22, n. 5, p. 557-563, 2010.
ISSN 0954-691X (Sherpa/Romeo, impact factor)
Publisher Lippincott Williams & Wilkins
Extent 557-563
Access rights Closed access
Type Article
Web of Science ID WOS:000277308600009

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