Behavioral evaluation of adult rats exposed in utero to maternal epileptic seizures

Behavioral evaluation of adult rats exposed in utero to maternal epileptic seizures

Author Lima, Daiana Correia Autor UNIFESP Google Scholar
Vale, Tiago Gurgel do Autor UNIFESP Google Scholar
Arganaraz, Gustavo Adolfo Autor UNIFESP Google Scholar
Vasconcelos Varella, Pedro Paulo Autor UNIFESP Google Scholar
Frussa-Filho, Roberto Autor UNIFESP Google Scholar
Cavalheiro, Esper Abrão Autor UNIFESP Google Scholar
Naffah-Mazzacoratti, Maria da Graca Autor UNIFESP Google Scholar
Amado, Debora Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract We investigated the effects of exposure to maternal convulsive seizures in utero on the behavior of offspring. An epilepsy model was induced in female rats by administration of pilocarpine. Seizure frequency was evaluated for 60 days. the rats were then allowed to mate, and seizure frequency during pregnancy was recorded and compared with prepregnancy frequency. After birth, placentas of mothers were submitted for histopathological analysis. the behavior of the offspring was evaluated 3 months after birth. There was a decline in seizure frequency even though the placentas from epileptic mothers showed areas of ischemic infarction indicative of fetal hypoxia. Offspring of epileptic mothers manifested deficits in motor coordination in the rotarod test and increased immobility in the open-field test. No changes in anxiety and depression-like behaviors were observed. These results suggest that in utero exposure to maternal seizures can produce motor deficits in adult life, perhaps as a result of fetal hypoxia. (C) 2010 Elsevier Inc. All rights reserved.
Keywords Pilocarpine epilepsy model
Pregnancy
Maternal seizures
Behavior
Motor coordination deficits
Hypoxia
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
ClnAPCe
INNT
Date 2010-05-01
Published in Epilepsy & Behavior. San Diego: Academic Press Inc Elsevier Science, v. 18, n. 1-2, p. 45-49, 2010.
ISSN 1525-5050 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 45-49
Origin http://dx.doi.org/10.1016/j.yebeh.2010.02.024
Access rights Closed access
Type Article
Web of Science ID WOS:000280018500007
URI http://repositorio.unifesp.br/handle/11600/32521

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