Degenerative parkinsonism in patients with psychogenic parkinsonism: A dopamine transporter imaging study

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dc.contributor.author Felicio, Andre C. [UNIFESP]
dc.contributor.author Godeiro-Junior, Clecio [UNIFESP]
dc.contributor.author Moriyama, Tais S. [UNIFESP]
dc.contributor.author Shih, Ming C. [UNIFESP]
dc.contributor.author Hoexter, Marcelo Q. [UNIFESP]
dc.contributor.author Borges, Vanderci [UNIFESP]
dc.contributor.author Silva, Sonia M. A. [UNIFESP]
dc.contributor.author Aguiar, Patricia de Carvalho [UNIFESP]
dc.contributor.author Andrade, Luiz A. F.
dc.contributor.author Bressan, Rodrigo A. [UNIFESP]
dc.contributor.author Ferraz, Henrique B. [UNIFESP]
dc.date.accessioned 2016-01-24T13:59:38Z
dc.date.available 2016-01-24T13:59:38Z
dc.date.issued 2010-05-01
dc.identifier http://dx.doi.org/10.1016/j.clineuro.2009.12.010
dc.identifier.citation Clinical Neurology and Neurosurgery. Amsterdam: Elsevier B.V., v. 112, n. 4, p. 282-285, 2010.
dc.identifier.issn 0303-8467
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/32509
dc.description.abstract Objectives: To evaluate patients with clinically established psychogenic parkinsonism (PsyP) using single-photon emission computer tomography (SPECT)with the technetium-99m labeled tracer TRODAT-1, a dopamine transporter (DAT) ligand, and investigate whether these patients have an underlying degenerative parkinsonism.Patients and methods: Five patients with PsyP were assessed using demographic data, standard clinical scales for Parkinson's Disease (PD), and a neuropsychiatric interview. DAT imaging using SPECT with TRODAT-1 was performed, and values for caudate/putamen DAT binding potentials (BP) registered. Patients with PsyP were matched with PD (n = 5) and healthy control subjects (n = 5).Results: the mean age (years-old) at first evaluation in the PsyP group was 37.4 +/- 3.7, and the mean disease duration (years) was 3.9 +/- 1.2. DAT BPs (means +/- standard deviations) on right/left caudate were, respectively, 0.69 +/- 0.18 and 0.70 +/- 0.18 in the PD group versus 1.17 +/- 0.06 and 1.12 +/- 0.10 in the control group. DAT BPs on right/left putamen were, respectively, 0.48 +/- 0.10 and 0.45 +/- 0.06 in the PD group versus 1.10 +/- 0.10 and 1.21 +/- 0.43 in the control group. Two out of five patients from the PsyP group had values for DAT BP in the putamen under the cut-off (<= 0.70) for controls, implying pre-synaptic dopaminergic deficit.Conclusions: Our data in this small group of patients suggest that DAT imaging is a tool that may help in the identification of underlying degenerative parkinsonism in PsyP. (C) 2009 Elsevier B.V. All lights reserved. en
dc.description.sponsorship Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorship Fondation Philanthropique Edmond J. Safra
dc.format.extent 282-285
dc.language.iso eng
dc.publisher Elsevier B.V.
dc.relation.ispartof Clinical Neurology and Neurosurgery
dc.rights Acesso restrito
dc.subject Psychogenic parkinsonism en
dc.subject Parkinson's Disease en
dc.subject SPECT en
dc.subject TRODAT-1 en
dc.subject Dopamine transporter en
dc.title Degenerative parkinsonism in patients with psychogenic parkinsonism: A dopamine transporter imaging study en
dc.type Artigo
dc.rights.license http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution H Israelita Albert Einstein
dc.description.affiliation Universidade Federal de São Paulo, UNIFESP, Dept Neurol, Movement Disorder Unit, São Paulo, Brazil
dc.description.affiliation H Israelita Albert Einstein, Inst Israelita Ensino & Pesquisa, São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Lab Interdisciplinar Neurociencias Clin, São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Dept Psychiat, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, UNIFESP, Dept Neurol, Movement Disorder Unit, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Lab Interdisciplinar Neurociencias Clin, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Psychiat, São Paulo, Brazil
dc.identifier.doi 10.1016/j.clineuro.2009.12.010
dc.description.source Web of Science
dc.identifier.wos WOS:000277836200003



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