Degenerative parkinsonism in patients with psychogenic parkinsonism: A dopamine transporter imaging study

Degenerative parkinsonism in patients with psychogenic parkinsonism: A dopamine transporter imaging study

Author Felicio, Andre C. Autor UNIFESP Google Scholar
Godeiro-Junior, Clecio Autor UNIFESP Google Scholar
Moriyama, Tais S. Autor UNIFESP Google Scholar
Shih, Ming C. Autor UNIFESP Google Scholar
Hoexter, Marcelo Q. Autor UNIFESP Google Scholar
Borges, Vanderci Autor UNIFESP Google Scholar
Silva, Sonia M. A. Autor UNIFESP Google Scholar
Aguiar, Patricia de Carvalho Autor UNIFESP Google Scholar
Andrade, Luiz A. F. Google Scholar
Bressan, Rodrigo A. Autor UNIFESP Google Scholar
Ferraz, Henrique B. Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
H Israelita Albert Einstein
Abstract Objectives: To evaluate patients with clinically established psychogenic parkinsonism (PsyP) using single-photon emission computer tomography (SPECT)with the technetium-99m labeled tracer TRODAT-1, a dopamine transporter (DAT) ligand, and investigate whether these patients have an underlying degenerative parkinsonism.Patients and methods: Five patients with PsyP were assessed using demographic data, standard clinical scales for Parkinson's Disease (PD), and a neuropsychiatric interview. DAT imaging using SPECT with TRODAT-1 was performed, and values for caudate/putamen DAT binding potentials (BP) registered. Patients with PsyP were matched with PD (n = 5) and healthy control subjects (n = 5).Results: the mean age (years-old) at first evaluation in the PsyP group was 37.4 +/- 3.7, and the mean disease duration (years) was 3.9 +/- 1.2. DAT BPs (means +/- standard deviations) on right/left caudate were, respectively, 0.69 +/- 0.18 and 0.70 +/- 0.18 in the PD group versus 1.17 +/- 0.06 and 1.12 +/- 0.10 in the control group. DAT BPs on right/left putamen were, respectively, 0.48 +/- 0.10 and 0.45 +/- 0.06 in the PD group versus 1.10 +/- 0.10 and 1.21 +/- 0.43 in the control group. Two out of five patients from the PsyP group had values for DAT BP in the putamen under the cut-off (<= 0.70) for controls, implying pre-synaptic dopaminergic deficit.Conclusions: Our data in this small group of patients suggest that DAT imaging is a tool that may help in the identification of underlying degenerative parkinsonism in PsyP. (C) 2009 Elsevier B.V. All lights reserved.
Keywords Psychogenic parkinsonism
Parkinson's Disease
SPECT
TRODAT-1
Dopamine transporter
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Fondation Philanthropique Edmond J. Safra
Date 2010-05-01
Published in Clinical Neurology and Neurosurgery. Amsterdam: Elsevier B.V., v. 112, n. 4, p. 282-285, 2010.
ISSN 0303-8467 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 282-285
Origin http://dx.doi.org/10.1016/j.clineuro.2009.12.010
Access rights Closed access
Type Article
Web of Science ID WOS:000277836200003
URI http://repositorio.unifesp.br/handle/11600/32509

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