Expression of a cell death marker (clusterin) in muscle target fibers

Expression of a cell death marker (clusterin) in muscle target fibers

Alternative title Expressão de marcador de morte celular programada (apoptosis) em fibras musculares com «target»
Author Oliveira, Acary Souza Bulle Autor UNIFESP Google Scholar
Corbo, Massimo Google Scholar
Duigou, Greg Google Scholar
Gabbai, Alberto Alain Autor UNIFESP Google Scholar
Hays, Arthur P. Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Columbia University College of Physicians and Surgeons Department of Neurosurgery
Abstract We report, for the first time, the expression of immunoractivity to clusterin in skeletal muscle. Clusterin, a protein probably related to the process of programmed cell death (apoptosis), was specifically very highly expressed in target fibers. All target fibers found in 50 muscle biopsy samples from a variety of neuromuscular disorders expressed a high concentration of clusterin in the middle of the targets. Clusterin was not expressed in any targetoid fibers or cores. Acute denervation, where targets are mostly seen, may be the beginning of apoptosis. Hence our findings support the concept that targets are harbingers of acute denervation.

Descrevemos, pela primeira vez, a expressão de imunorreatividade para clusterina em músculo esquelético. Clusterina, proteína relacionada ao processo de morte celular programada (apoptosis), encontrou-se especificamente muito aumentada em fibras musculares com «target» (FT). Todas as FT encontradas em 50 biópsias musculares de pacientes com diferentes doenças neuromusculares apresentaram alta concentração de clusterina no centro das FT. Clusterina não esteve semelhantemente aumentada em fibras com «targetóide» ou com «core». A alta expressão de clusterina em «targets» indica que FT podem ser o início de apoptosis e que há íntima relação entre FT e desnervação aguda.
Keywords skeletal muscle
target
clusterin
músculo esquelético
fibras com «target»
clusterina
Language English
Date 1993-09-01
Published in Arquivos de Neuro-Psiquiatria. Academia Brasileira de Neurologia - ABNEURO, v. 51, n. 3, p. 371-376, 1993.
ISSN 0004-282X (Sherpa/Romeo)
Publisher Academia Brasileira de Neurologia - ABNEURO
Extent 371-376
Origin http://dx.doi.org/10.1590/S0004-282X1993000300014
Access rights Open access Open Access
Type Article
SciELO ID S0004-282X1993000300014 (statistics in SciELO)
URI http://repositorio.unifesp.br/handle/11600/325

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