Autonomic impairment after myocardial infarction: Role in cardiac remodelling and mortality

Autonomic impairment after myocardial infarction: Role in cardiac remodelling and mortality

Author Mostarda, C. Autor UNIFESP Google Scholar
Rodrigues, B. Google Scholar
Vane, M. Google Scholar
Moreira, E. D. Google Scholar
Rosa, K. T. Google Scholar
Moraes-Silva, I. C. Google Scholar
Lacchini, S. Google Scholar
Casarini, D. E. Autor UNIFESP Google Scholar
De Angelis, K. Google Scholar
Irigoyen, M. C. Google Scholar
Institution Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Univ Sao Judas Tadeu
Abstract P>1. Impairmant of baroreflex sensitivity (BRS) has been implicated in the reduction of heart rate variability (HRV) and in the increased risk of death after myocardial infarction (MI). in the present study, we investigated whether the additional impairment in BRS induced by sinoaortic baroreceptor denervation (SAD) in MI rats is associated with changes in the low-frequency (LF) component of HRV and increased mortality rate.2. Rats were randomly divided into four groups: control, MI, denervated (SAD) and SAD + MI rats. Left ventricular (LV) function was evaluated by echocardiography. Autonomic components were assessed by power spectral analysis and BRS.3. Myocardial infarction (90 days) reduced ejection fraction (by similar to 42%) in both the MI and SAD + MI groups; however, an increase in LV mass and diastolic dysfunction were observed only in the SAD + MI group. Furthermore, BRS, HRV and the LF power of HRV were reduced after MI, with an exacerbated reduction seen in SAD + MI rats. the LF component of blood pressure variability (BPV) was increased in the MI, SAD and SAD + MI groups compared with the control group. Mortality was higher in the MI groups compared with the non-infarcted groups, with an additional increase in mortality in the SAD + MI group compared with the MI group. Correlations were obtained between BRS and the LF component of HRV and between LV mass and the LF component of BPV.4. Together, the results indicate that the abolishment of BRS induced by SAD in MI rats further reduces the LF band of HRV, resulting in a worse cardiac remodelling and increased mortality in these rats. These data highlight the importance of this mechanism in the prognosis of patients after an ischaemic event.
Keywords baroreflex
left ventricular function
mortality
myocardial infarction
spectral analysis
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Fundacao EJ Zerbini
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Grant number FAPESP: 01/00009-0
FAPESP: 07/57595-5
Date 2010-04-01
Published in Clinical and Experimental Pharmacology and Physiology. Malden: Wiley-Blackwell Publishing, Inc, v. 37, n. 4, p. 447-452, 2010.
ISSN 0305-1870 (Sherpa/Romeo, impact factor)
Publisher Wiley-Blackwell
Extent 447-452
Origin http://dx.doi.org/10.1111/j.1440-1681.2009.05327.x
Access rights Closed access
Type Article
Web of Science ID WOS:000275766900009
URI http://repositorio.unifesp.br/handle/11600/32450

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