Birthweight and the risk of childhood-onset type 1 diabetes: a meta-analysis of observational studies using individual patient data

Birthweight and the risk of childhood-onset type 1 diabetes: a meta-analysis of observational studies using individual patient data

Author Cardwell, Chris R. Google Scholar
Stene, Lars Christian Google Scholar
Joner, Geir Google Scholar
Davis, Elizabeth Anne Google Scholar
Cinek, Ondrej Google Scholar
Rosenbauer, Joachim Google Scholar
Ludvigsson, Jhonny Google Scholar
Castell, Conxa Google Scholar
Svensson, Jannet Google Scholar
Goldacre, Michael J. Google Scholar
Waldhoer, Thomas Google Scholar
Polanska, Joanna Google Scholar
Gimeno, Suely Godoy Agostinho Autor UNIFESP Google Scholar
Chuang, Lee Ming Google Scholar
Parslow, Roger C. Google Scholar
Wadsworth, Emma J. K. Google Scholar
Chetwynd, Amanda Google Scholar
Pozzilli, Paolo Google Scholar
Brigis, G. Google Scholar
Urbonaite, Brone Google Scholar
Sipetic, Sandra Google Scholar
Schober, Edith Google Scholar
Ionescu-Tirgoviste, Constantin Google Scholar
Beaufort, Carine E. de Google Scholar
Stoyanov, Denka Google Scholar
Buschard, Karsten Google Scholar
Patterson, Chris Christopher Google Scholar
Institution Queens Univ Belfast
Norwegian Inst Publ Hlth
Oslo Univ Hosp
Univ Oslo
Univ Western Australia
Charles Univ Prague
Univ Dusseldorf
Linkoping Univ
Advisory Comm Diabet Catalonia
Glostrup Univ Hosp
Univ Oxford
Med Univ Vienna
Silesian Tech Univ
Universidade Federal de São Paulo (UNIFESP)
Natl Taiwan Univ Hosp
Univ Leeds
Cardiff Univ
Univ Lancaster
Univ Campus Biomed
Riga Stradins Univ
Kaunas Univ Med
Univ Belgrade
N Paulescu Inst Diabet
Pediat Clin
Childrens Diabet Ctr
Abstract We investigated whether children who are heavier at birth have an increased risk of type 1 diabetes.Relevant studies published before February 2009 were identified from literature searches using MEDLINE, Web of Science and EMBASE. Authors of all studies containing relevant data were contacted and asked to provide individual patient data or conduct pre-specified analyses. Risk estimates of type 1 diabetes by category of birthweight were calculated for each study, before and after adjustment for potential confounders. Meta-analysis techniques were then used to derive combined ORs and investigate heterogeneity between studies.Data were available for 29 predominantly European studies (five cohort, 24 case-control studies), including 12,807 cases of type 1 diabetes. Overall, studies consistently demonstrated that children with birthweight from 3.5 to 4 kg had an increased risk of diabetes of 6% (OR 1.06 [95% CI 1.01-1.11]; p = 0.02) and children with birthweight over 4 kg had an increased risk of 10% (OR 1.10 [95% CI 1.04-1.19]; p = 0.003), compared with children weighing 3.0 to 3.5 kg at birth. This corresponded to a linear increase in diabetes risk of 3% per 500 g increase in birthweight (OR 1.03 [95% CI 1.00-1.06]; p = 0.03). Adjustments for potential confounders such as gestational age, maternal age, birth order, Caesarean section, breastfeeding and maternal diabetes had little effect on these findings.Children who are heavier at birth have a significant and consistent, but relatively small increase in risk of type 1 diabetes.
Keywords Birthweight
Risk factors
Type 1 diabetes mellitus
Language English
Sponsor Czech Republic Ministry of Education
Department of Health in Taiwan
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Centro Internazionale Studi Diabete (Italy, Rome)
Swedish Child Diabetes Foundation
NHS National Coordinating Centre for Research Capacity Development UK
Research Council of Norway
German Research Foundation
Ministry for Science and Technological Development of Serbia
European Commission Health Information Strand
Diabetes UK
Northern Ireland Department of Health and Social Services
Grant number Czech Republic Ministry of Education: 0021620814
Department of Health in Taiwan: DOH 92- TD1052
FAPESP: 94/0943-0
German Research Foundation: HE 234/1-1
Ministry for Science and Technological Development of Serbia: 145084
European Commission Health Information Strand: 2007115
Date 2010-04-01
Published in Diabetologia. New York: Springer, v. 53, n. 4, p. 641-651, 2010.
ISSN 0012-186X (Sherpa/Romeo, impact factor)
Publisher Springer
Extent 641-651
Access rights Closed access
Type Article
Web of Science ID WOS:000275087100008

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