Craniopharyngiomas: intratumoral chemotherapy with interferon-alpha: a multicenter preliminary study with 60 cases

Craniopharyngiomas: intratumoral chemotherapy with interferon-alpha: a multicenter preliminary study with 60 cases

Author Cavalheiro, Sergio Autor UNIFESP Google Scholar
Di Rocco, Concezzio Google Scholar
Valenzuela, Sergio Google Scholar
Dastoli, Patricia A. Autor UNIFESP Google Scholar
Tamburrini, Gianpiero Google Scholar
Massimi, Lucca Google Scholar
Nicacio, Jardel M. Autor UNIFESP Google Scholar
Faquini, Igor V. Autor UNIFESP Google Scholar
Ierardi, Daniela F. Autor UNIFESP Google Scholar
Silva, Nasjla Saba Autor UNIFESP Google Scholar
Pettorini, Benedetta Ludovica Google Scholar
Toledo, Silvia Regina Caminada de Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Univ Cattolica Sacro Cuore
Neurosurg Inst Santiago
Policlin Gemelli
Abstract Object. the authors assessed the efficacy of intratumoral interferon-alpha (IFN alpha)-based chemotherapy in pediatric patients with cystic craniopharyngiomas.Methods. in a prospective multicenter study of 60 pediatric patients, the authors assessed the efficacy of intratumoral INF alpha 2A-based chemotherapy. the study was conducted between 2000 and 2009 at 3 locations: the Medical School of the Federal University of São Paulo, Catholic University of Rome, and the Neurosurgery Institute of Santiago, Chile. the assessment included clinical and radiological control examinations, side effects observed, and total dose used.Results. Sixty cases of cystic craniopharyngioma were analyzed. the cohort consisted of 35 male and 25 female children (mean age 11 years). Clinical and radiological improvement was achieved in 76% of the cases. New endocrinological deficits were observed in 13% of the cases. in approximately 30% of the patients, the evolution included some light side effects, the most common being headache (33%) and eyelid edema (28%). the number of cycles varied from 1 to 9 (mean 5 cycles), and the total dose applied per cycle was 36,000,000 IU.Conclusions. This has been the largest documented series of intratumoral chemotherapy using INF alpha for the control of cystic craniopharyngiomas. the treatment has proved efficacious; there was no mortality, and morbidity rates were low. (DOI: 10.3171/2010.1.FOCUS09310)
Keywords craniopharyngioma
interferon-alpha
hypothalamus
obesity
diabetes insipidus
Language English
Date 2010-04-01
Published in Neurosurgical Focus. Rolling Meadows: Amer Assoc Neurological Surgeons, v. 28, n. 4, 5 p., 2010.
ISSN 1092-0684 (Sherpa/Romeo, impact factor)
Publisher Amer Assoc Neurological Surgeons
Extent 5
Origin http://dx.doi.org/10.3171/2010.1.FOCUS09310
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000276212900015
URI http://repositorio.unifesp.br/handle/11600/32396

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