Association Analysis of Endothelial Nitric Oxide Synthase G894T Gene Polymorphism and Erectile Dysfunction Complaints in a Population-Based Survey

Association Analysis of Endothelial Nitric Oxide Synthase G894T Gene Polymorphism and Erectile Dysfunction Complaints in a Population-Based Survey

Author Andersen, Monica L. Autor UNIFESP Google Scholar
Guindalini, Camila Autor UNIFESP Google Scholar
Santos-Silva, Rogerio Autor UNIFESP Google Scholar
Bittencourt, Lia Rita A. Autor UNIFESP Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Introduction.Erectile dysfunction (ED) is a common disorder leading to a serious, negative impact on the quality of the patient's life. the gene encoding endothelial nitric oxide synthase (eNOS) is an interesting candidate gene for understanding the physiopathology of ED, as it is involved in the catalytic production of nitric oxide (NO), the neurotransmitter that plays a critical role in penile tumescence and erection.Aim.To evaluate a potential association between the G894T polymorphism in the eNOS gene and ED complaints in a population-based sample in São Paulo, Brazil.Main Outcome Measures.The prevalence of ED complaints was estimated according to the answer to the question How would you describe your ability to get and keep an erection that is adequate for satisfactory intercourse? ED was considered to be present if the response was sometimes or never.Methods.A total of 449 men were enrolled in the study and answered an eight-item questionnaire to ascertain sexual performance/ED and satisfaction. the eNOS G894T polymorphism was genotyped using a standard polymerase chain reaction method.Results.Univariate analysis demonstrated that ED was associated with diabetes, hypertension, sleep apnea severity, increasing age and body mass index, as well as testosterone levels (P < 0.05). Forward multiple regression models indicated that age was the only independent factor associated with ED in this population (odds ratio = 1.09; 95% CI 1.06-1.11; P < 0.0001). Genotypic and allelic analyses provided no evidence for an association between this polymorphism and the risk for ED complaints in this sample. Population stratification did not affect the association test results.Conclusions.This is the first study to examine the effect of polymorphisms in the eNOS gene and the risk for ED utilizing a case-control approach in the Brazilian population. Our results do not support a major role for eNOS gene polymorphisms in ED in this population. Andersen ML, Guindalini C, Santos-Silva R, Bittencourt LRA, and Tufik S. Association analysis of endothelial nitric oxide synthase G894T gene polymorphism and erectile dysfunction complaints in a population-based survey. J Sex Med 2010;7:1229-1236.
Keywords Erectile Dysfunction
Polymorphism
eNos Gene
No Synthase
Sleep Apnea
G894T
Diabetes
Hypertension
Testosterone
Population Study of Erectile Dysfunction
Language English
Sponsor Associacao Fundo de Incentivo a Psicofarmacologia (AFIP)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
CEPID
Grant number FAPESP: 07/50525-1
CEPID: 98/14303-3
Date 2010-03-01
Published in Journal of Sexual Medicine. Malden: Wiley-Blackwell Publishing, Inc, v. 7, n. 3, p. 1229-1236, 2010.
ISSN 1743-6095 (Sherpa/Romeo, impact factor)
Publisher Wiley-Blackwell
Extent 1229-1236
Origin http://dx.doi.org/10.1111/j.1743-6109.2009.01606.x
Access rights Closed access
Type Article
Web of Science ID WOS:000275099700020
URI http://repositorio.unifesp.br/handle/11600/32374

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