PINK1 polymorphism IVS1-7 A -> G, exposure to environmental risk factors and anticipation of disease onset in Brazilian patients with early-onset Parkinson's Disease

PINK1 polymorphism IVS1-7 A -> G, exposure to environmental risk factors and anticipation of disease onset in Brazilian patients with early-onset Parkinson's Disease

Author Godeiro Junior, Clecio Autor UNIFESP Google Scholar
Carvalho Aguiar, Patricia M. de Autor UNIFESP Google Scholar
Felicio, Andre C. Autor UNIFESP Google Scholar
Barsottini, Orlando G. P. Autor UNIFESP Google Scholar
Silva, Sonia M. A. Autor UNIFESP Google Scholar
Borges, Vanderci Autor UNIFESP Google Scholar
Andrade, Luiz Augusto Franco de Autor UNIFESP Google Scholar
Ferraz, Henrique Ballalai Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Hosp Israelita Albert Einstein
Abstract Parkinson's disease (PD) etiology has been attributed both to genetic and environmental factors, although the exact mechanisms of its pathogenesis remains elusive. We investigated Brazilian early-onset PD (EOPD) patients with PINK1 polymorphisms (SNPs) in order to find possible correlations between SNPs, environmental exposure, and disease age of onset. We enrolled 48 patients and 61 controls. PINK1 SNPs and environmental exposure (living in rural areas, well-water drinking, exposure to pesticides, herbicides and organic solvents and smoking)were investigated in both groups. We divided our group, of patients into four subgroups, according to the presence/absence of PINK1 SNP IVS1-7 A --> G and the presence/absence of environmental factors exposure. We found a significant decrease (ANOVA test: p = 0.02) of age at disease onset in those patients that had the IVS1-7 A G SNP and were exposed to environmental risk factors. Our data suggest that the interaction of PINK1 SNP IVS1-7 A --> G and environmental risk factors together have an important role in EOPD: each of them individually has a minor influence, whereas their interaction is associated with a significant effect in anticipating the disease clinical onset. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
Keywords PINK1
Early-onset Parkinson's Disease
Environmental exposure
Disease modifier
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Date 2010-01-18
Published in Neuroscience Letters. Clare: Elsevier B.V., v. 469, n. 1, p. 155-158, 2010.
ISSN 0304-3940 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 155-158
Origin http://dx.doi.org/10.1016/j.neulet.2009.11.064
Access rights Closed access
Type Article
Web of Science ID WOS:000274565500033
URI http://repositorio.unifesp.br/handle/11600/32174

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