Single exposure to cocaine or ecstasy induces DNA damage in brain and other organs of mice

Single exposure to cocaine or ecstasy induces DNA damage in brain and other organs of mice

Author Alvarenga, Tathiana A. Autor UNIFESP Google Scholar
Andersen, Monica L. Autor UNIFESP Google Scholar
Ribeiro, Daniel A. Google Scholar
Araujo, Paula Autor UNIFESP Google Scholar
Hirotsu, Camila Autor UNIFESP Google Scholar
Costa, Jose L. Google Scholar
Battisti, Murilo C. Autor UNIFESP Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract We evaluated the overall genetic damage induced by different doses of cocaine and MDMA (3,4-Methylenedioxymethamphetamine) in several organs. One hour after intraperitoneal drug administration, mice were euthanized; peripheral blood, liver and brain were collected, and the cellular suspensions were used for the single cell gel (comet) assay. We determined that all doses of cocaine and MDMA tested were able to induce DNA damage in blood cells. Extensive genotoxic damage was induced by cocaine or MDMA at the highest doses used in liver cells. Brain cells were affected by all doses administrated. These findings demonstrate that cocaine and MDMA are potent genotoxins.
Keywords Acute administration
cocaine
DNA damage
ecstasy
MDMA
single cell gel (comet) assay
Language English
Sponsor AFIP
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Grant number FAPESP: CEPID 98/14303-3
FAPESP: 09/01030-5
FAPESP: 07/01228-4
Date 2010-01-01
Published in Addiction Biology. Malden: Wiley-Blackwell Publishing, Inc, v. 15, n. 1, p. 96-99, 2010.
ISSN 1355-6215 (Sherpa/Romeo, impact factor)
Publisher Wiley-Blackwell
Extent 96-99
Origin http://dx.doi.org/10.1111/j.1369-1600.2009.00179.x
Access rights Closed access
Type Article
Web of Science ID WOS:000272565100010
URI http://repositorio.unifesp.br/handle/11600/32136

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