Qualitative analysis of hippocampal plastic changes in rats with epilepsy supplemented with oral omega-3 fatty acids

Qualitative analysis of hippocampal plastic changes in rats with epilepsy supplemented with oral omega-3 fatty acids

Author Cysneiros, Roberta M. Google Scholar
Ferrari, Danuza Autor UNIFESP Google Scholar
Arida, Ricardo M. Autor UNIFESP Google Scholar
Terra, Vera C. Google Scholar
Almeida, Antonio-Carlos G. de Google Scholar
Cavalheiro, Esper A. Autor UNIFESP Google Scholar
Scorza, Fulvio A. Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Univ Presbiteriana Mackenzie
Universidade de São Paulo (USP)
Univ Fed Sao Joao Del Rei
Abstract Studies have provided evidence of the important effects of omega-3 fatty acid on the brain in neurological conditions, including epilepsy. Previous data have indicated that omega-3 fatty acids lead to prevention of status epilepticus-associated neuropathological changes in the hippocampal formation of rats with epilepsy. Omega-3 fatty acid supplementation has resulted in extensive preservation of GABAergic cells in animals with epilepsy. This study investigated the interplay of these effects with neurogenesis and brain-derived neurotrophic factor (BDNF). the results clearly showed a positive effect of long-term omega-3 fatty acid supplementation on brain plasticity in animals with epilepsy. Enhanced hippocampal neurogenesis and BDNF levels and preservation of interneurons expressing parvalbumin were observed. Parvalbumin-positive cells were identified as surviving instead of newly formed cells. Additional investigations are needed to determine the electrophysiological properties of the newly formed cells and to clarify whether the effects of omega-3 fatty acids on brain plasticity are accompanied by functional gain in animals with epilepsy. (C) 2009 Elsevier Inc. All rights reserved.
Keywords Omega-3 fatty acids
Epilepsy
Neurogenesis
Brain-derived neurotrophic factor
Oral supplementation
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
CinAPCe (Brazil)
Date 2010-01-01
Published in Epilepsy & Behavior. San Diego: Academic Press Inc Elsevier Science, v. 17, n. 1, p. 33-38, 2010.
ISSN 1525-5050 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 33-38
Origin http://dx.doi.org/10.1016/j.yebeh.2009.11.006
Access rights Closed access
Type Article
Web of Science ID WOS:000273837700004
URI http://repositorio.unifesp.br/handle/11600/32116

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