Can living in the surroundings of a petrochemical complex be a risk factor for autoimmune thyroid disease?

Can living in the surroundings of a petrochemical complex be a risk factor for autoimmune thyroid disease?

Author Freitas, Clarice Umbelino de Google Scholar
Grimaldi Campos, Rosaria A. Google Scholar
Rodrigues Silva, Mirta Alcira F. Google Scholar
Panachao, Maria Rosana I. Google Scholar
Moraes, Jose Cassio de Google Scholar
Waissmann, William Google Scholar
Chacra, Antonio Roberto Autor UNIFESP Google Scholar
Maeda, Marina Y. S. Google Scholar
Minazzi Rodrigues, Regina S. Google Scholar
Belchor, James Goncalves Google Scholar
Barbosa, Sonia Oliveira Google Scholar
Santos, Raimunda Telma M. Google Scholar
Institution CVE SES SP
Santa Casa Misericordia Hosp
Fiocruz MS
Universidade Federal de São Paulo (UNIFESP)
IAL SES SP
Maua City Dept Hlth
Santo Andre City Dept Hlth
Abstract Background: Based on a suspicion raised by a health professional and due to a subsequent legal request, a cross-sectional study was made with a comparison group to investigate a possible excess of Hashimoto's thyroiditis-HT and antibodies-ATA in the surroundings of a Petrochemical Complex.Methods: People of both sexes aged over 20 years were investigated in a random sample of residents in the area surrounding the Petrochemical Complex. Controls were investigated in an area with steel industries. in the areas searched, participants were chosen randomly and stratified a priori by sex and age group. As a result, 90.5% of the expected sample was obtained, totaling 1533 individuals. HT and ATA prevalences were compared by the chi-square test. Logistic regression was used to control the possible confounding factors for HT and ATA.Results: Both TH (9.3%) and ATA (17.6%) prevalences were higher in the Petrochemical Complex area than in the control area (3.9% and 10.3%, respectively). After controlling the possible confounding factors, the POR for living in the surroundings of the Complex and presenting HT was 2.39 (CI95%: 1.42-4.03). According to the ATA criterion, the POR for living in the surroundings of the Complex was 1.78 (CI95%: 1.23-2.60).Conclusions: the authors have found higher prevalence and risk of developing thyroiditis and antithyroid antibodies among residents of areas surrounding the Petrochemical Complex and think these findings need to be further studied in similar areas. (C) 2009 Elsevier Inc. All rights reserved.
Keywords Hashimoto's thyroiditis
Anti-thyroid antibodies
Petrochemical plant
Prevalence
Surveillance
Language English
Sponsor Coordenacao de Controle de Doen as (CCD)
Date 2010-01-01
Published in Environmental Research. San Diego: Academic Press Inc Elsevier Science, v. 110, n. 1, p. 112-117, 2010.
ISSN 0013-9351 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 112-117
Origin http://dx.doi.org/10.1016/j.envres.2009.10.009
Access rights Closed access
Type Article
Web of Science ID WOS:000273942000016
URI http://repositorio.unifesp.br/handle/11600/32094

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