Comparison of laser Doppler imaging, fingertip lacticemy test, and nailfold capillaroscopy for assessment of digital microcirculation in systemic sclerosis

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dc.contributor.author Correa, Marcelo J. U. [UNIFESP]
dc.contributor.author Andrade, Luis E. C. [UNIFESP]
dc.contributor.author Kayser, Cristiane [UNIFESP]
dc.date.accessioned 2016-01-24T13:59:02Z
dc.date.available 2016-01-24T13:59:02Z
dc.date.issued 2010-01-01
dc.identifier http://dx.doi.org/10.1186/ar3112
dc.identifier.citation Arthritis Research & Therapy. London: Biomed Central Ltd, v. 12, n. 4, 8 p., 2010.
dc.identifier.issn 1478-6354
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/32045
dc.description.abstract Introduction: Laser Doppler imaging (LDI) is a relatively new method for assessing the functional aspect of superficial skin blood flow in systemic sclerosis (SSc) and Raynaud's phenomenon. the present study investigated the dynamic behavior of digital skin microvascular blood flow before and after cold stimulus (CS) in SSc patients and in healthy controls by means of a comprehensive approach of the functional (LDI), morphological (nailfold capillaroscopy (NFC)), and biochemical (fingertip lacticemy (FTL)) microcirculation components.Methods: Forty-four SSc patients and 40 healthy controls were included. After acclimatization, all subjects underwent NFC followed by LDI and FTL measurement. NFC was performed with a stereomicroscope under 10x to 20x magnification in the 10 digits of the hands. Skin blood flow of the dorsum of four fingertips (excluding the thumb) of the left hand was measured using LDI at baseline and for 30 minutes after CS. the mean finger blood flow (FBF) of the four fingertips was expressed as arbitrary perfusion units. FTL was determined on the fourth left finger before (pre-CS-FTL) and 10 minutes after CS.Results: LDI showed significantly lower mean baseline FBF in SSc patients as compared with controls (296.9 +/- 208.8 vs. 503.6 +/- 146.4 perfusion units; P < 0.001) and also at all time points after CS (P < 0.001). There was a significant decrease in mean FBF after CS as compared with baseline in SSc patients and in controls, followed by recovery of the blood flow 27 minutes after CS in healthy controls, but not in SSc patients. FBF tended to be lower in patients with digital scars and previous ulceration/amputation (P = 0.06). There was no correlation between mean baseline FBF and NFC parameters. Interestingly, there was a negative correlation between FTL and FBF measured by LDI in basal conditions and 10 minutes after CS in SSc patients.Conclusions: LDI showed lower digital blood flow in SSc patients when compared with healthy controls and correlated well with FTL both at baseline and after CS, allowing objective measurement of blood perfusion in SSc patients. the lack of correlation between functional and morphological microvascular abnormalities, measured by LDI and NFC, suggests they are complementary tools for evaluation of independent microangiopathy aspects in SSc patients. en
dc.description.sponsorship Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorship Brazilian Society of Rheumatology Research Agency
dc.format.extent 8
dc.language.iso eng
dc.publisher Biomed Central Ltd
dc.relation.ispartof Arthritis Research & Therapy
dc.rights Acesso aberto
dc.title Comparison of laser Doppler imaging, fingertip lacticemy test, and nailfold capillaroscopy for assessment of digital microcirculation in systemic sclerosis en
dc.type Artigo
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Universidade Federal de São Paulo, Div Rheumatol, Dept Med, BR-04023062 São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Div Rheumatol, Dept Med, BR-04023062 São Paulo, Brazil
dc.description.sponsorshipID FAPESP: 06/59073-3
dc.identifier.file WOS000283841500031.pdf
dc.identifier.doi 10.1186/ar3112
dc.description.source Web of Science
dc.identifier.wos WOS:000283841500031



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