Prolonged consumption of soy or fish-oil-enriched diets differentially affects the pattern of hypothalamic neuronal activation induced by refeeding in rats

Prolonged consumption of soy or fish-oil-enriched diets differentially affects the pattern of hypothalamic neuronal activation induced by refeeding in rats

Author Watanabe, Regina L. H. Google Scholar
Andrade, Iracema S. Google Scholar
Zemdegs, Juliane C. S. Google Scholar
Albuquerque, Kelse T. Autor UNIFESP Google Scholar
Nascimento, Claudia M. O. Google Scholar
Oyama, Lila M. Autor UNIFESP Google Scholar
Carmo, Maria G. T. Google Scholar
Nogueira, Maria I. Google Scholar
Ribeiro, Eliane B. Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Universidade Federal do Rio de Janeiro (UFRJ)
Universidade de São Paulo (USP)
Abstract We used c-Fos immunoreactivity to estimate neuronal activation in hypothalamic feeding-regulatory areas of 3-month-old rats fed control or oil-enriched diets (soy or fish) since weaning. While no diet effect was observed in c-Fos immunoreactivity of 24-h fasted animals, the acute response to refeeding was modified by both hyperlipidic diets but with different patterns. Upon refeeding, control-diet rats had significantly increased c-Fos immunoreactivity only in the paraventricular hypothalamic nucleus (PVH, 142%). in soy-diet rats, refeeding with the soy diet increased c-Fos immunoreactivity in dorsomedial hypothalamic nucleus (DMH, 271%) and lateral hypothalamic area (LH, 303%). Refeeding fish-diet rats with the fish diet increased c-Fos immunoreactivity in PVH (161%), DMH (177%), VMH (81%), and ARC (127%). Compared to the fish-diet, c-Fos immunoreactivity was increased in LH by the soy-diet while it was decreased in ventromedial hypothalamic nucleus (VMH) and arcuate hypothalamic nucleus (ARC). Based on the known roles of the activated nuclei, it is suggested that, unlike the fish-diet, the soy-diet induced a potentially obesogenic profile, with high LH and low VMH/PVH activation after refeeding.
Keywords appetite regulation
hypothalamus
c-Fos immunoreactivity
hyperlipidic diet
soy oil
fish oil
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Date 2009-12-01
Published in Nutritional Neuroscience. Leeds: Maney Publishing, v. 12, n. 6, p. 242-248, 2009.
ISSN 1028-415X (Sherpa/Romeo, impact factor)
Publisher Maney Publishing
Extent 242-248
Origin http://dx.doi.org/10.1179/147683009X423472
Access rights Closed access
Type Article
Web of Science ID WOS:000272047800001
URI http://repositorio.unifesp.br/handle/11600/32010

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