Transcervical hysteroscopic sterilization using cyanoacrylate: A long-term experimental study on sheep

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dc.contributor.author Bigolin, Sergio
dc.contributor.author Fagundes, Djalma José [UNIFESP]
dc.contributor.author Rivoire, Henri Chaplin
dc.contributor.author Negrini Fagundes, Anna Tereza [UNIFESP]
dc.contributor.author Negrini Fagundes, Anna Luiza
dc.date.accessioned 2016-01-24T13:58:59Z
dc.date.available 2016-01-24T13:58:59Z
dc.date.issued 2009-12-01
dc.identifier http://dx.doi.org/10.1111/j.1447-0756.2009.01075.x
dc.identifier.citation Journal of Obstetrics and Gynaecology Research. Malden: Wiley-Blackwell Publishing, Inc, v. 35, n. 6, p. 1012-1018, 2009.
dc.identifier.issn 1341-8076
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/32005
dc.description.abstract Aim:We investigated the transcervical hysteroscopy application of n-butyl-2-cyanoacrylate in the uterine tube lumen of a non-rodent animals (sheep) with fallopian tube dimensions similar those in humans.Methods:Standard hysteroscopic procedures were performed on female Texel sheep (n = 26). the right and left ostia were identified. for each ewe, a urethral catheter (5Fr) was used for the delivery of 0.5 mL of saline or an equal volume of n-butyl-2-cyanoacrylate into the uterine tube. Following the procedure, ewes were housed with males of proven fertility for 90 days (equivalent to 5.5 estrous cycles). Postmortem (dye and burst pressure) and in vivo (hysterosalpingogram) testing for tube patency were both performed 90 days and 180 days following the procedure.Results:All animals receiving the saline treatment became pregnant. Gross inspection of uterine tubes following n-butyl-2-cyanoacrylate treatment revealed no visceral adhesions or fibrosis. However, postmortem testing revealed total obstruction within the fallopian tubes. This was confirmed by hysterosalpingogram, in that iodine contrast did not escape into the abdominal cavity.Conclusion:The cyanoacrylate promoted a reliable fallopian tube obstruction without fibrosis in an animal model exhibiting a similar tube diameter to that found in women. the technique can be evaluated for efficacy in vivo using hysterosalpingography. en
dc.description.sponsorship Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.format.extent 1012-1018
dc.language.iso eng
dc.publisher Wiley-Blackwell
dc.relation.ispartof Journal of Obstetrics and Gynaecology Research
dc.rights Acesso restrito
dc.subject experimental surgery en
dc.subject reproductive sterilization en
dc.subject sheep en
dc.subject surgical adhesive en
dc.subject uterine tube en
dc.title Transcervical hysteroscopic sterilization using cyanoacrylate: A long-term experimental study on sheep en
dc.type Artigo
dc.rights.license http://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Univ Santo Amaro
dc.contributor.institution Reg Integrated Univ High Uruguay & Missions
dc.contributor.institution Rio Grande Fed Univ
dc.description.affiliation Universidade Federal de São Paulo, Paulista Med Sch, São Paulo, Brazil
dc.description.affiliation Univ Santo Amaro, São Paulo, Brazil
dc.description.affiliation Reg Integrated Univ High Uruguay & Missions, Rio Grande Do Sul, Brazil
dc.description.affiliation Rio Grande Fed Univ, Rio Grande Do Sul, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Paulista Med Sch, São Paulo, Brazil
dc.identifier.doi 10.1111/j.1447-0756.2009.01075.x
dc.description.source Web of Science
dc.identifier.wos WOS:000272344200002



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