Factors associated with the progression of hepatic fibrosis in end-stage kidney disease patients with hepatitis C virus infection

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dc.contributor.author Becker, Vitoria R. [UNIFESP]
dc.contributor.author Badiani, Rosilene das Graças [UNIFESP]
dc.contributor.author Lemos, Lara B. [UNIFESP]
dc.contributor.author Perez, Renata M.
dc.contributor.author Medina-Pestana, Jose O. [UNIFESP]
dc.contributor.author Lanzoni, Valeria P. [UNIFESP]
dc.contributor.author Ferreira, Adalgisa R.
dc.contributor.author Silva, Antonio Eduardo B. [UNIFESP]
dc.contributor.author Ferraz, Maria Lucia G. [UNIFESP]
dc.date.accessioned 2016-01-24T13:58:59Z
dc.date.available 2016-01-24T13:58:59Z
dc.date.issued 2009-12-01
dc.identifier http://dx.doi.org/10.1097/MEG.0b013e328313bbc1
dc.identifier.citation European Journal of Gastroenterology & Hepatology. Philadelphia: Lippincott Williams & Wilkins, v. 21, n. 12, p. 1395-1399, 2009.
dc.identifier.issn 0954-691X
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/32003
dc.description.abstract Background Few studies have evaluated the histological aspects of hepatitis C virus (HCV) infection in hemodialysis patients and the factors related to the progression of hepatic fibrosis in this population have not been defined.Aim To evaluate the influence of host-related factors on the fibrosis progression in end-stage renal disease (ESRD) patients with HCV infection.Methods HCV-infected ESRD patients who submitted to liver biopsy were included. the fibrosis stages were classified according to METAVIR scoring system. for the identification of factors associated with more advanced liver fibrosis, the patients were classified into two groups: group 1, absence of septal fibrosis (F0-1) and group 2, presence of septal fibrosis (F2-4). Groups 1 and 2 were compared regarding demographic, epidemiological, and laboratory variables and logistic regression analysis was used to identify the variables that were independently associated with the presence of septal fibrosis.Results A total of 216 ESRD patients (63% men, 44 +/- 11 years) were included. in the histological analysis, the fibrosis stages were as follows: F0=36%, F1 =41%, F2 = 12%, F3 = 7, and 4% had cirrhosis (F4). in the logistic regression model, the variables that were independently associated with the presence of septal fibrosis were duration of infection, estimated age at infection, coinfection with HBV and aspartate aminotransferase levels.Conclusion These findings support the importance of obtaining an adequate immune response to HBV vaccination and careful monitoring of liver disease in patients who become infected at an advanced age and/or those presenting elevated aspartate aminotransferase levels, as these are the main factors associated with the presence of septal fibrosis in ESRD patients. Eur J Gastroenterol Hepatol 21:1395-1399 (C) 2009 Wolters Kluwer Health | Lippincott Williams & Wilkins. en
dc.format.extent 1395-1399
dc.language.iso eng
dc.publisher Lippincott Williams & Wilkins
dc.relation.ispartof European Journal of Gastroenterology & Hepatology
dc.rights Acesso restrito
dc.subject end-stage kidney disease en
dc.subject hepatic fibrosis en
dc.subject hepatitis C en
dc.title Factors associated with the progression of hepatic fibrosis in end-stage kidney disease patients with hepatitis C virus infection en
dc.type Artigo
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Univ Fed Maranhao
dc.contributor.institution Universidade Federal do Rio de Janeiro (UFRJ)
dc.description.affiliation Universidade Federal de São Paulo, Div Gastroenterol, Rio de Janeiro, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Div Nephrol, Rio de Janeiro, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Dept Pathol, Rio de Janeiro, Brazil
dc.description.affiliation Univ Fed Maranhao, Dept Internal Med, Rio de Janeiro, Brazil
dc.description.affiliation Univ Fed Rio de Janeiro, Dept Internal Med, Rio de Janeiro, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Div Gastroenterol, Rio de Janeiro, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Div Nephrol, Rio de Janeiro, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Pathol, Rio de Janeiro, Brazil
dc.identifier.doi 10.1097/MEG.0b013e328313bbc1
dc.description.source Web of Science
dc.identifier.wos WOS:000272115800012



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