Ghrelin and GHRP-6-induced ACTH and cortisol release in thyrotoxicosis

Ghrelin and GHRP-6-induced ACTH and cortisol release in thyrotoxicosis

Author Nascif, Sergio Oliva Autor UNIFESP Google Scholar
Molica, Patricia Autor UNIFESP Google Scholar
Correa-Silva, Silvia Regina Autor UNIFESP Google Scholar
Silva, Marcos Roberto Autor UNIFESP Google Scholar
Lengyel, Ana-Maria Judith Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Thyrotoxicosis might alter the hypothalamic-pituitary-adrenal (HPA) axis. We evaluated the effects of ghrelin and GHRP-6 on the HPA axis in 20 hyperthyroid patients and in 9 controls. Mean basal cortisol (mu g/dl) and ACTH (pg/ml) levels were higher in hyperthyroidism (cortisol: 10.7 +/- A 0.7; ACTH: 21.5 +/- A 2.9) compared to controls (cortisol: 8.1 +/- A 0.7; ACTH: 13.5 +/- A 1.8). in thyrotoxicosis a dagger AUC cortisol values (mu g/dl.90 min) after ghrelin (484 +/- A 80) and GHRP-6 (115 +/- A 63) were similar to controls (ghrelin: 524 +/- A 107; GHRP-6: 192 +/- A 73). A significant increase in a dagger AUC ACTH (pg/ml.90 min) after ghrelin was observed in thyrotoxicosis (4,189 +/- A 1,202) compared to controls (1,499 +/- A 338). a dagger AUC ACTH values after GHRP-6 were also higher, although not significantly (patients: 927 +/- A 330; controls: 539 +/- A 237). in summary, our results suggest that ghrelin-mediated pathways of ACTH release might be activated by thyroid hormone excess, but adrenocortical reserve is maintained.
Keywords Ghrelin
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Date 2009-12-01
Published in Pituitary. New York: Springer, v. 12, n. 4, p. 315-321, 2009.
ISSN 1386-341X (Sherpa/Romeo, impact factor)
Publisher Springer
Extent 315-321
Access rights Closed access
Type Article
Web of Science ID WOS:000270977600006

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