From Galapagos to the labs: Darwinian medicine and epilepsy today

From Galapagos to the labs: Darwinian medicine and epilepsy today

Author Scorza, Fulvio A. Autor UNIFESP Google Scholar
Cysneiros, Roberta M. Google Scholar
Terra, Vera C. Google Scholar
Arida, Ricardo M. Autor UNIFESP Google Scholar
Scorza, Carla A. Autor UNIFESP Google Scholar
Cavalheiro, Esper A. Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Univ Presbiteriana Mackenzie
Universidade de São Paulo (USP)
Abstract In 1991, a mummy frozen in ice was found by climbers in the Tyrolean Alps. Otzi the Iceman has since been studied in the light of evolutionary explanations for diseases. This year, which marks Charles Darwin's 200th birthday and the 150th anniversary of his publication On the Origin of Species, should re-ignite discussion of the importance of the correlation between nutritional diet and diseases. Epilepsy is one of the commonest diseases in the world. Individuals with epilepsy are at higher risk of death than the general population, and Sudden unexpected death (SUDEP) is the most important direct epilepsy-related Cause of death. A number of factors may influence the risk for SUDEP. Along these lines, several studies have demonstrated that polyunsaturated (omega-3) fatty acids may reduce the risk of cardiovascular mortality, and diminish neuronal excitability. Also, omega-3 fatty acids may decrease seizure frequency, contributing to the reduction of SUDEP risk. Reconstruction of the nutritional patterns of Stone Age humans and optimal human nutrition in the present may be relevant to the prevention and treatment of chromic diseases such as epilepsy and the catastrophic evolution into epilepsy refractoriness and SUDEP. (C) 2009 Elsevier Inc. All rights reserved.
Keywords Darwin
Omega-3 fatty acids
Sudden unexplained death in epilepsy
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Date 2009-11-01
Published in Epilepsy & Behavior. San Diego: Academic Press Inc Elsevier Science, v. 16, n. 3, p. 388-390, 2009.
ISSN 1525-5050 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 388-390
Access rights Closed access
Type Review
Web of Science ID WOS:000271935800003

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