Correlation between memory, proton magnetic resonance spectroscopy, and interictal epileptiform discharges in temporal lobe epilepsy related to mesial temporal sclerosis

Correlation between memory, proton magnetic resonance spectroscopy, and interictal epileptiform discharges in temporal lobe epilepsy related to mesial temporal sclerosis

Author Silva Mantoan, Marcele Araujo Autor UNIFESP Google Scholar
Sales Ferreira Caboclo, Luis Otavio Autor UNIFESP Google Scholar
Figueiredo Ferreira Guilhoto, Laura Maria de Autor UNIFESP Google Scholar
Lin, Katia Autor UNIFESP Google Scholar
Silva Noffs, Maria Helena da Autor UNIFESP Google Scholar
Silva Tudesco, Ivanda de Souza Autor UNIFESP Google Scholar
Belzunces, Erich Autor UNIFESP Google Scholar
Carrete, Henrique Autor UNIFESP Google Scholar
Bussoletti, Renato Tavares Autor UNIFESP Google Scholar
Centeno, Ricardo Silva Autor UNIFESP Google Scholar
Sakamoto, Americo Ceiki Autor UNIFESP Google Scholar
Targas Yacubian, Elza Marcia Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Objective: the aim of the study described here was to examine the relationship between memory function, proton magnetic resonance spectroscopy ((1)H-MRS) abnormalities, and interictal epileptiform discharge (IED) lateralization in patients with temporal lobe epilepsy (TLE) related to unilateral mesial temporal sclerosis.Methods: We assessed performance on tests of memory function and intelligence quotient (IQ) in 29 right-handed outpatients and 24 controls. IEDs were assessed on 30-minute-awake and 30-minute-sleep EEG samples. Patients had (1)H-MRS at 1.5 T.Results: There was a negative correlation between IQ (P = 0.031) and Rey Auditory Verbal Learning Test results (P = 0.022) and epilepsy duration: between (1)H-MRS findings and epilepsy duration (P = 0.027); and between N-acetylaspartate (NAA) levels and IEDs (P = 0.006) in contralateral mesial temporal structures in the left MTS group. (1)H-MRS findings, IEDs, and verbal function were correlated.Conclusions: These findings suggest that IEDs and NAA/(Cho + Cr) ratios reflecting neural metabolism are closely related to verbal memory function in mesial temporal sclerosis. Higher interictal activity on the EEG was associated with a decline in total NAA in contralateral mesial temporal structures. (C) 2009 Elsevier Inc. All rights reserved.
Keywords Memory
Neuropsychology
Proton magnetic resonance spectroscopy
Interictal epileptiform discharges
Temporal lobe epilepsy
Mesial temporal sclerosis
Language English
Date 2009-11-01
Published in Epilepsy & Behavior. San Diego: Academic Press Inc Elsevier Science, v. 16, n. 3, p. 447-453, 2009.
ISSN 1525-5050 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 447-453
Origin http://dx.doi.org/10.1016/j.yebeh.2009.08.032
Access rights Closed access
Type Article
Web of Science ID WOS:000271935800016
URI http://repositorio.unifesp.br/handle/11600/31933

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