Treatment of recurrent aphthous stomatitis with clofazimine

Treatment of recurrent aphthous stomatitis with clofazimine

Author Milanez Morgado de Abreu, Marilda Aparecida Google Scholar
Watashi Hirata, Cleonice Hitomi Autor UNIFESP Google Scholar
Pimentel, Dalva Regina Neto Autor UNIFESP Google Scholar
Weckx, Luc Louis Maurice Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Objective. the aim was to investigate the safety and efficacy of clofazimine for the treatment of recurrent aphthous stomatitis.Study design. in this randomized controlled partially blind study, 23 patients received clofazimine 100 mg daily for 30 days and then 100 mg every other day. Twenty-three patients received colchicine 0.5 mg 3 times daily. Twenty patients received 1 placebo pill 2 times daily. All subjects received medications for 6 months. the chi-squared or Fisher exact tests were used to assess drug efficacy with respect to objective findings and symptoms.Results. A greater percentage of individuals in the clofazimine group had no further aphthous episodes (17%-44% compared with <= 6% in the other groups). A significantly greater percentage of treatment interruption occurred in the colchicine group because of gastrointestinal effects (23%-45%). Individuals in the clofazimine group who continued to suffer from aphthous stomatitis presented with better results for the evaluated variables.Conclusion. Clofazimine should be considered for the treatment of recurrent aphthous stomatitis. (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2009;108:714-721)
Language English
Date 2009-11-01
Published in Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology. New York: Mosby-Elsevier, v. 108, n. 5, p. 714-721, 2009.
ISSN 1079-2104 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 714-721
Origin http://dx.doi.org/10.1016/j.tripleo.2009.05.009
Access rights Closed access
Type Article
Web of Science ID WOS:000270903000016
URI http://repositorio.unifesp.br/handle/11600/31930

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