Infection by the Sylvio X10/4 clone of Trypanosoma cruzi: relevance of a low-virulence model of Chagas' disease

Infection by the Sylvio X10/4 clone of Trypanosoma cruzi: relevance of a low-virulence model of Chagas' disease

Author Marinho, Claudio R. F. Autor UNIFESP Google Scholar
Nunez-Apaza, Luis N. Google Scholar
Bortoluci, Karina R. Autor UNIFESP Google Scholar
Bombeiro, Andre L. Google Scholar
Bucci, Daniella Z. Google Scholar
Grisotto, Marcos G. Google Scholar
Sardinha, Luiz R. Google Scholar
Jorquera, Christian E. Google Scholar
Lira, Sergio Google Scholar
D'Imperio Lima, Maria Regina Google Scholar
Alvarez, Jose M. Google Scholar
Institution Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Mt Sinai Sch Med
Abstract The physiopathology of Chagas' disease has been largely defined in murine infections with virulent strains which partially represent parasite diversity This report reviews our studies with Sylvio X10/4 parasites. a Trypanosoma cruzi clone that induces no acute phase but in C3H/He mice leads to chronic myocarditis resembling the human disease. Crown Copyright (C) 2009 Published by Elsevier Masson SAS All rights reserved
Keywords Chagas' disease
Trypanosoma cruzi
Sylvio X10/4 parasites
Parasitaemia
Heart pathology
Immune response
Parasite evasion
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Date 2009-11-01
Published in Microbes and Infection. Amsterdam: Elsevier B.V., v. 11, n. 13, p. 1037-1045, 2009.
ISSN 1286-4579 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 1037-1045
Origin http://dx.doi.org/10.1016/j.micinf.2009.07.011
Access rights Closed access
Type Review
Web of Science ID WOS:000271557300006
URI http://repositorio.unifesp.br/handle/11600/31927

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