Stress, immunity and skin collagen integrity: Evidence from animal models and clinical conditions

Stress, immunity and skin collagen integrity: Evidence from animal models and clinical conditions

Author Kahan, V. Autor UNIFESP Google Scholar
Andersen, M. L. Autor UNIFESP Google Scholar
Tomimori, J. Autor UNIFESP Google Scholar
Tufik, S. Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract The skin is the largest organ of the human body and plays a major role in maintaining homeostasis and protection. As the main component of skin, collagen has a key role in providing integrity and elasticity to this organ. Several factors, including autoimmune disease, aging, and stress, can change the quantity and integrity of skin collagen. These factors impair collagen quality and consequently affect skin function. Stress seems to affect the integrity of skin collagen through glucocorticoid-mediated processes that alter its synthesis and degradation. Glucocorticoids also affect skin quality through modulation of the immune system. This review will briefly present comprehensive data from both animal and human studies delineating processes that modulate alterations in collagen in general, and will treat in more detail the consequences of stress on skin collagen. (C) 2009 Elsevier Inc. All rights reserved.
Keywords Skin integrity
Collagen
Stress
Immune system
Glucocorticoids
Aging
Sleep deprivation
Language English
Sponsor Associacao Fundo de Incentivo a Psicofarmacologia (AFIP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Grant number FAPESP: 98/14303-3
Date 2009-11-01
Published in Brain Behavior and Immunity. San Diego: Academic Press Inc Elsevier Science, v. 23, n. 8, p. 1089-1095, 2009.
ISSN 0889-1591 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 1089-1095
Origin http://dx.doi.org/10.1016/j.bbi.2009.06.002
Access rights Closed access
Type Review
Web of Science ID WOS:000271754700008
URI http://repositorio.unifesp.br/handle/11600/31922

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