Childhood radiation-associated atypical meningioma with novel complex rearrangements involving chromosomes 1 and 12

Childhood radiation-associated atypical meningioma with novel complex rearrangements involving chromosomes 1 and 12

Author Brassesco, Maria Sol Google Scholar
Valera, Elvis Terci Google Scholar
Neder, Luciano Google Scholar
Castro-Gamero, Angel Mauricio Google Scholar
Oliveira, Fabio Morato de Google Scholar
Santos, Antonio Carlos Google Scholar
Scrideli, Carlos Alberto Google Scholar
Oliveira, Ricardo Santos Google Scholar
Machado, Helio Rubens Google Scholar
Tone, Luiz Gonzaga Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Abstract Meningiomas are recognized as the most common late complication following radiotherapy. However, cytogenetic studies in childhood atypical radiation-induced meningioma are sporadic, mainly because this condition generally occurs after a long latent period. in the present study we show the results of conventional and molecular cytogenetics in a 14-year-old boy with a secondary atypical meningioma. Apart from numerical changes, we found complex aberrations with the participation of chromosomes 1, 6 and 12. the invariable presence of loss of 1p was demonstrated by fluorescent in situ hybridization (FISH) analysis with probes directed to telomeric regions and by comparative genome hybridization (CGH). Previous cytogenetic studies on adult spontaneous and radiation-associated meningiomas showed loss of chromosome 22 as the most frequent change, followed by loss of the short arm of chromosome 1. To the best of our knowledge this is the first report of highly complex chromosome aberrations in the pediatric setting of meningioma.
Keywords children
chromosomes 1 and 12
complex rearrangements
radiation-induced meningioma
Language English
Sponsor Fundacao de Amparo Pesquisa do Estado de São Paulo
Grant number Fundacao de Amparo Pesquisa do Estado de São Paulo: 07/54236-4
Fundacao de Amparo Pesquisa do Estado de São Paulo: 06/04827-3
Date 2009-10-01
Published in Neuropathology. Malden: Wiley-Blackwell Publishing, Inc, v. 29, n. 5, p. 585-590, 2009.
ISSN 0919-6544 (Sherpa/Romeo, impact factor)
Publisher Wiley-Blackwell
Extent 585-590
Origin http://dx.doi.org/10.1111/j.1440-1789.2008.00991.x
Access rights Closed access
Type Article
Web of Science ID WOS:000270153100010
URI http://repositorio.unifesp.br/handle/11600/31876

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